Wnt信号通路与支气管肺发育不良  

Wnt signaling pathway and bronchopulmonary dysplasia

作　　者：王少华（综述）[1] 许峰（审校）[1] 

机构地区：[1]重庆医科大学附属儿童医院PICU,400014

出　　处：《国际儿科学杂志》2012年第1期43-45,共3页International Journal of Pediatrics

基　　金：国家自然科学基金资助项目（30973218）

摘　　要：Wnt信号通路是一条在进化上保守的信号传导途径，主要由经典的Wnt／β-catenin途径和非经典的Wnt／平面细胞极性途径及Wnt／Ca^2＋途径组成，该通路从多个水平参与肺发育及多种肺部疾病过程。支气管肺发育不良（bronchopulmonary dysplasia，BPD）是在肺发育不成熟基础上由于炎症损伤及损伤后肺纤维化异常修复所导致的慢性肺疾病。该文就Wnt信号通路与肺发育、肺部炎症和肺纤维化的关系作一综述，以期揭示Wnt信号通路与BPD之间的可能联系，为BPD的防治提供新的切人点。Wnt signaling pathway is an conserved signaling pathway. Three signaling pathways are typically described for Wnt proteins：the canonical Wnt/β-catenin pathway, the noncanonical pathways including the polar cell polarity pathway and the Wnt/Ca^2＋ pathway. The complex components have diverse roles in regulating lung development and lung diseases. Bronchopulmonary dysplasia（BPD） is one of chronic lung diseases based on the immature lung due to inflammation damage and abnormal repair of pulmonary fibrosis after injury. This paper reviewed the roles of Wnt pathway in lung development, inflammation and pulmonary fibrosis in hope of revealing potential links between Wnt pathway and BPD.

关 键 词：WNT信号通路 肺发育 炎症 肺纤维化 支气管肺发育不良 

分 类 号：R722.6[医药卫生—儿科]