男性不育症患者血清抗精子抗体与精子质量的关系  

Analysis of sperm quality and testing result of serum AsAb in male patients with sterility

作　　者：季明勇[1] 黄明孔[1] 马天根[1] 郭建[1] 

机构地区：[1]成都中医药大学第二附属医院,四川生殖卫生医院,成都610041

出　　处：《中国男科学杂志》2011年第11期49-51,共3页Chinese Journal of Andrology

摘　　要：目的观察抗精子抗体（AsAb）对男性不育症患者精子质量的影响及临床意义。方法男性不育患者553例检测血清AsAb和精液后分为两组，一组为AsAb阳性组（140例），另一组为AsAb阴性组（413例）。统计两组患者精液精子密度、活率及活力的指标，两组间进行比较，观察它们之间的差异。同时取正常生育男性60例作为对照组，男性不育AsAb阳性组与正常生育组进行比较，观察它们之间的差异。结果男性不育症553例血清AsAb检测有3种结果：抗体阴性413例（占74．7％）、精子凝集抗体（TAT）阳性122例（占22．1％）、精子凝集抗体＋精子制动抗体（TAT＋SIT）阳性18例（占3．2％）；无单独精子制动抗体SIT检出。男性不育AsAb阳性组与阴性组、正常生育组精子质量经统计学比较，精子密度、活率、活力差异均有统计学意义（P〈0．05）。结论抗精子抗体检测在免疫性不育诊断和治疗中具有临床意义和参考价值。Objective To investigate influence of anti sperm antibody （AsAb） on sperm quality and its clinical significance in male patients with sterility. Methods： 553 male patients with sterility were collected. Serum AsAb and semen were tested. 140 male patients with sterility with positive AsAb and ones with negative AsAb were classified. Sperm density, viability and activity were measured. Then date was processed in two groups to reveal the difference. Meanwhile, 60 male with normal reproduction were collected as control. Group with positive AsAb was compared with. Results： In total 553 patients, 413 （74.7%） were revealed negative AsAb, 122 （22.1%） were revealed positive TAT and 18 were revealed positive TAT＋SIT. There was no solo positive SIT. Sperm density, viability and activity in group of positive AsAb in patients with sterility indicated significant difference （P〈0.05）. Conclusion Testing of AsAb has certain clinical significance in diagnosis and management of immune sterility.

关 键 词：不育 男性 精子 

分 类 号：R698.2[医药卫生—泌尿科学]