钆贝葡胺致过敏性休克  

Anaphylactic shock by gadobenate dimeglumine

作　　者：刘丽芳[1] 魏璇[1] 

机构地区：[1]空军总医院老年病科,北京100142

出　　处：《药物不良反应杂志》2011年第6期386-387,共2页Adverse Drug Reactions Journal

摘　　要：1例59岁女性患者因行磁共振成像增强扫描静脉注射钆贝葡胺15 ml。10s后,患者出现刺激性咳嗽、左臂针刺样疼痛、面部肿胀感。10 min后出现头晕、视物模糊、心悸、胸闷等症状并持续加重,血压降至70/40 mm Hg(1 mm Hg=0.133kPa)。考虑为钆贝葡胺引起的过敏性休克。立即给予地塞米松、氢化可的松、葡萄糖酸钙、异丙嗪、多巴胺、去甲肾上腺素等药物治疗并快速补液。1 h后上述症状缓解。24 h后患者血压120/60 mmHg、心率92次/min。A 59-year-old female patient received IV gadobenate dimeglumine 15 ml for enhanced MRI scan.Ten seconds later,the patient experienced irritating cough,tingling in her left arm,and facial swelling.After 10 minutes,she developed dizziness,blurred vision,palpitation,chest distress and her symptoms continued to worsen.Her blood pressure decreased to 70/40 mm Hg.Gadobenate dimeglumine-induced anaphylactic shock was considered.The patient was given dexamethasone,hydrocortisone,calcium gluconate,promethazine,dopamine,norepinephrine,and a rapid fluid infusion.After an hour,the above-mentioned symptoms relieved and,after 24 hours,her blood pressure was 120/60 mmHg and her heart rate was 92 beats/min.

关 键 词：钆贝葡胺 磁共振成像 过敏性休克 

分 类 号：R593.1[医药卫生—内科学]