上海市2010年强化免疫活动中麻疹减毒活疫苗和麻疹-流行性腮腺炎-风疹联合减毒活疫苗的安全性观察  

Safety Surveillance of Measles Attenuated Live Vaccine and Measles-Mumps-Rubella Combined Attenuated Live Vaccine after Supplementary Immunization Activities in Shanghai,2010

作　　者：白庆瑞[1] 杨建萍[1] 陆菁[1] 黄卓英[1] 李智[1] 王于超[1] 秦晓东[1] 陶黎纳[1] 胡家瑜[1] 

机构地区：[1]上海市疾病预防控制中心,上海200336

出　　处：《中国疫苗和免疫》2011年第6期526-530,544,共6页Chinese Journal of Vaccines and Immunization

摘　　要：目的了解上海市2010年强化免疫活动(Supplementary Immunization Activites,SIA)中,麻疹减毒活疫苗(Measles Attenuated Live Vaccine,MV)和麻疹-流行性腮腺炎-风疹联合减毒活疫苗(Measles,Mumpsand Rubella Combined Attenuated Live Vaccine,MMR)的安全性。方法通过上海市疑似预防接种异常反应(Adverse Events Following Immunization,AEFI)监测系统收集MV和MMR联合疫苗的AEFI信息,分析其AEFI发生情况。结果 2010年9月11日～10月20日,上海市SIA共接种81.40万剂MV和97.75万剂MMR联合疫苗。MV的一般反应和异常反应报告发生率分别为109.33/10万剂和13.51/10万剂,MMR联合疫苗一般反应和异常反应报告发生率分别为20.87/10万剂和3.99/10万剂。MV的AEFI病例中,年龄越小所占构成比越大。两种疫苗的AEFI均以发热和局部红肿等一般反应为主,报告的异常反应中以过敏性皮疹为主。结论使用MV或MMR联合疫苗进行SIA安全性良好。Objective To investigate the safety of the measles attenuated live vaccine （MV） and measles- mumps-rubella combined attenuated live vaccine （MMR）after the supplementary immunization activities （SIA） in Shanghai in 2010. Methods The surveillance data was analyzed which were collected through Shanghai adverse events following immunization （AEFI）surveillance system. Results From September 11, 2010 to October 20, 2010, 0.814 million children were vaccinated by MV and 0.9775 million were vaccinated by MMR. The reported rate of common adverse reaction of MV was 109.33/100,000 and 13.51/100,000, respectively. The reported rate of rare adverse reaction of MMR was 20.87/100,000 and 3.99/100,000, respectively. The younger group is the greater proportion of reported MV AEFI cases. The reported AEFI was mainly common adverse reaction, such as fever and local swelling. The rare adverse reaction was mostly allergic rash. Conclusions The vaccination of MV and MMR in SIA was safe and the most reaction was common adverse reaction.

关 键 词：麻疹减毒活疫苗 麻疹-流行性腮腺炎-风疹联合减毒活疫苗 强化免疫活动 安全性 疑似预防接种异常反应 

分 类 号：R186[医药卫生—流行病学]