肌钙蛋白T、肌酸激酶、肌酸激酶同工酶MB亚型对新生儿心脏损害诊断的临床应用  

Clinical diagnostic application of TnT、CK、CK MB for myocardial injury in newborns.

作　　者：李济振[1] 刘玉华[1] 程鸿瑜 冯秀河[1] 袁晓明 纪丽 刘雪清 

机构地区：[1]河北医科大学附属沧州二医院检验科,061000 [2]沧州市第三医院

出　　处：《河北医药》2000年第2期102-103,共2页Hebei Medical Journal

摘　　要：目的 　 探讨成人心脏损害诊断的生化标志物 :肌钙蛋白T、肌酶激酶 (CK)、肌酸激酶同工酶MB亚型 (CK MB)对新生儿心脏损害的临床应用情况 ,并得出新生儿正常参考值。方法　按实验要求 ,把不同情况的材料分成不同类别组 ,然后分别进行测定 ,对结果再行总结分析。结果　对于这几个生化指标 ,成人正常参考值不适用于新生儿。新生儿分别为 :早产 :CK 72 0U/L ,CK MB 110U/L ;足月产 :CK 2 40 0U/L ,CK MB 3 0 0U/L ,肌钙蛋白T(TnT) :与孕期无关 ,0 .3 3g/L。结论 　 对新生儿心脏损害的诊断 ,CK MB没有实际临床应用价值 。Objective To investigate clinical value of biochemical markers:Troponin T、CK、CK MB in myocardial injury of newborns.Methods According to test request,the newborns who suffered from different diseases were divided into different groups,the marks in infants were detected,then the results were evaluated and analysed. Results Adult normal reference values of the marks aren't fit for newborns,newborns are:CK:preterm:720 U/L,fullterm:2400 U/L;CK MB:preterm:110 U/L;full term:300 U/L;TnT which has no rehationship with gestatiand age is 0.33 g/L. Conclusion There isn’t clinical application value for CK、CK MB to diagnose myocardial injury in newborns,only TnT is specific biochemical mark.

关 键 词：肌钙蛋白T CK CK-MB 新生儿 心脏损害 诊 

分 类 号：R541.04[医药卫生—心血管疾病] R540.4[医药卫生—内科学]