不同类型的急性冠脉综合征患者血清热休克蛋白60浓度比较研究  

Compare the Serum Concentrations of Heat Shock Protein 60 Among the Patients with Various Type of Acute Coronary Syndrome

作　　者：杨政杰[1] 杨承健[1] 张月军[1] 全文超[1] 秦娴[1] 

机构地区：[1]江苏省无锡市第二人民医院心内科,江苏无锡214002

出　　处：《现代生物医学进展》2011年第24期4945-4947,共3页Progress in Modern Biomedicine

摘　　要：目的:了解急性冠脉综合征(ACS)发作时热休克蛋白60(HSP60)及其抗体的血清浓度变化情况。方法:测定各类不稳定性心绞痛(UA,n=32)、S-T段抬高性心肌梗死(STEMI,n=16)和非ST段抬高性心肌梗死(NSTEMI,n=8)和健康对照(n=38)血清HSP60及其抗体的浓度并作统计学比较。结果:各型ACS患者血清HSP60和抗体水平均显著高于对照组(P<0.05),且STEMI患者血清HSP和抗体水平显著高于UA和NSTEMI患者(P<0.05)。结论:测定患者血清HSP60水平可以用于协助ACS诊断和疾病进程监测。Objective： To investigative the serum concentrations of heat shock protein 60（HSP60） and its antibody in acute coro-nary syndrome（ACS） patients.Methods： Patients with unstable angina（UA,n=32）,ST-segment elevation myocardial infarction（STEMI,n=16）,or non-STEMI（NSTEMI,n=8） and 38 healthy controls were enrolled and their serum HSP60 and its antibody were measured.Results： In compare with healthy controls,patients with ACS have higher level of HSP60 and antibody（P0.05）.HSP60 and antibody level was higher in the patients with STEMI than those in the patients with UA or NSTEMI（P0.05）.Conclusions： Serum HSP60 and its antibody could be used to diagnose ACS or to get to know the disease progression.

关 键 词：急性冠脉综合征 热休克蛋白60 

分 类 号：R541.4[医药卫生—心血管疾病]