过敏性紫癜患儿血浆组织型纤溶酶原激活物及其抑制物的变化与肾脏损伤的关系  

Correlation between plasma tissue-type plasminogen activator and inhibitor-1 with kidney damage in children with Henoch-Schonlein Purpura

作　　者：刘钧菲[1] 王华[1] 

机构地区：[1]郑州大学第一附属医院儿内2科,450052

出　　处：《中国实用医刊》2012年第3期18-20,共3页Chinese Journal of Practical Medicine

摘　　要：目的观察过敏性紫癜（HSP）患儿血浆组织型纤溶酶原激活物（t-PA）、凝血酶原激活抑制物-1（PAI-1）水平的变化，探讨其与肾脏损伤的关系。方法采用双抗体夹心ELISA方法测定血浆t-PA、PAI—1并加以分析。结果合并肾脏损害（A）组t—PA、PAI-1急性期和恢复期均高于对照组，t-PA／PAI-1均低于对照组，差异有统计学意义（P均〈0．01）；无肾脏损害（B）组t—PA、PAI—1急性期升高，与正常对照组比较差异有统计学意义（P均〈0．01），恢复期降至正常，t-PA／PAI-1急性期和恢复期与正常对照组比较差异无统计学意义；A组t—PA急性期低于B组，恢复期高于B组，PAI-1急性期和恢复期均高于B组，t-PA／PAI-1均低于B组，差异有统计学意义（P均〈0．01）。结论纤溶系统功能的削弱可能与过敏性紫癜肾脏损伤的发生有关。Objective To observe the changes of plasma levels of tissue-type plasminogen acti- vator and inhibitor-1, and its relationship with kidney damage in children with Henoch-Schonlein Purpu- ra. Methods Plasma levels of tissue-type plasminogen activator （t-PA） and plasminogen activator inhibitor-1 （ PAI-1 ） were measured by enzyme-linked immunosorbent assay. Results Plasma levels of t-PA and PAI-1 in children with Henoch-Schonlein Purpura with kidney damage（ group A） were significantly higher than those of the controls in acute phase and recovery phase （P 〈 0.01 ）. The levels of t-PA/ PAI-1 in group A were significantly lower than those of the controls in acute phase and recovery phase （P 〈 0. 01 ） ; Plasma levels of t-PA and PAI-1 in children with Henoch-Schonlein Purpura without kidney damage （ group B） were significantly higher than those of the controls in acute phase （P 〈 0.01 ） and reduced to normal in recovery phase. The levels of t-PA/PAI-1 in group B were normal in acute phase and recovery phase ; The levels of t-PA in group A were significantly lower in acute phase and significantly higher in recovery phase than those in group B （ P 〈 0.01 ）. The levels of PAI-1 in group A were significantly higher than those in group B in acute phase and recovery phase （P 〈 0.01 ）. The levels of t- PA/PAI-1 in group A were significantly lower than those in group B in acute phase and recovery phase （P 〈 0. 001 ）. Conclusions Impairment of the fibrinolytic system maybe related to the kidney damage in children with Henoch-Schonlein Purpura.

关 键 词：儿童 过敏性紫癜 肾炎 组织型纤溶酶原激活物 凝血酶原激活抑制物-1 

分 类 号：R725.5[医药卫生—儿科]