应用受试者工作曲线评价血浆脑钠肽浓度水平对呼吸困难患者鉴别诊断的价值  

To estimate the differential diagnosis value of plasma concentrations of brain natriuretic peptide(NT-proBNP) on patients with dyspnea using receiver operating characteristic curve(ROC curve)

作　　者：邵良荣[1] 邵杰[2] 

机构地区：[1]东南大学医学院附属盐城医院,江苏224001 [2]南京中医药大学第一临床医学院,210046

出　　处：《国际检验医学杂志》2011年第21期2442-2443,2445,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨ROC曲线评价血浆脑钠肽(NT-proBNP)对鉴别心源性呼吸困难和非心源性呼吸困难的临床诊断价值。方法采用化学发光检测仪(强生VITROS 5600全自动生化免疫整合系统)定量检测心源性呼吸困难、非心源性呼吸困难患者(包括对照组)血清NT-proBNP浓度水平,并绘制ROC曲线。结果心源性呼吸困难患者的NT-proBNP浓度水平明显高于非心源性呼吸困难患者及对照组,差异有统计学意义(P<0.01);其ROC曲线下面积为0.89,临界值为600pg/mL,敏感性、特异性分别为80.77%、85.23%。结论血浆NT-proBNP浓度水平可以作为鉴别心源性呼吸困难和非心源性呼吸困难的一个有价值的临床指标。Objective To evaluate the clinical diagnostic value of plasma brain natriuretic peptide（NT-proBNP） with the receiver operating characteristic curve（ROC curve） to identificate cardiac dyspnea and non-cardiac dyspnea.Methods Quantitative detection of serum concentration of NT-proBNP of cardiac dyspna and non-cardiac dyspnea（including the normal control） was done by chemiluminescence detector-Johnson Johnson VITROS 5600 automatic integration of biological immune system,and the ROC curve was drawn.Results The concentrations of NT-proBNP in serum of patients with cardiac dyspnea were significantly higher than that of non-cardiac dyspnea and normal controls.The difference was statistically significant（P0.01）.The area under ROC curve of cardiopulmonary dyspnea was 0.89 with critical value of 600 pg/mL whose sensitivity and specificity were 80.77%,85.23% respectively.Conclusion The concentrations of NT-proBNP in serum can be used as a valuable clinical indicator to identify cardiac dyspnea and non-cardiac dyspnea.

关 键 词：呼吸困难 诊断 鉴别 ROC曲线 N末端脑钠肽 

分 类 号：R541.6[医药卫生—心血管疾病]