血清视黄醇结合蛋白对评价早期肾损伤的诊断价值  

Evaluation of serum retinol-binding protein on the early diagnosis of renal injury

作　　者：汪明东[1] 孙立山[1] 郑慧雅[1] 陆柳[1] 范列英[1] 

机构地区：[1]上海同济大学附属东方医院检验科,200120

出　　处：《国际检验医学杂志》2011年第21期2448-2449,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨血清视黄醇结合蛋白(RBP)对早期肾损伤的诊断价值。方法采用免疫比浊法检测343例肾病患者及200例健康人血清RBP的变化。用酶法检测其血清肌酐(Cr)的变化,并由简化MDRD公式计算出估计的肾小球滤过率(GFR)。结果肾功正常组RBP的结果与对照组比较,差异有统计学意义(P<0.05),且RBP在四组中的任意两组之间比较都差异有统计学意义(P<0.05),而血清Cr在正常健康组、肾功正常组和肾功轻度受损组之间差异无统计学意义(P>0.05)。结论 RBP可作为诊断肾病早期损害的敏感性指标,同时检测血清Cr有助于提高其阳性率,但血RBP的敏感性优于血清Cr。Objective To explore the evaluation of retinol-binding protein（RBP） on the early diagnosis of renal injury.Methods The changes of serum RBP were determined in 200 healthy subjects and 343 patients with nephropathy by immune transmission nephelometry.And the changes of serum creatinine（Cr） by enzyme,Estimate GFR（eGFR） was estimated with Modification of Diet in Renal Disease（MDRD） equations.Results The levels of serum retinol-binding protein in the normal renal function group were higher than those in the control group（P0.05）,the levels of serum retinol-binding were in the four groups between any two groups had significant differences（P0.05）.The levels of serum creatinine were not significant among the groups of the control group and the normal renal function group and the slight renal function group（P0.05）.Conclusion The serum retinol-binding protein can be used as a sensitive indicator for the diagnosis of early renal damage in nephropathy.It contributes to improving the positive rate to measure serum creatinine at the same time,and the sensitiveness of serum retinol-binding protein is superior to serum creatinine.

关 键 词：视黄醇结合蛋白类 估计的肾小球滤过率 MDRD公式 

分 类 号：R692[医药卫生—泌尿科学]