早产儿乙肝疫苗接种时机、剂量研究和远期效果评价  

Long-term effects of Hepatitis B vaccination inoculation time and dose in preterm children

作　　者：王章星 唐群芳 童燕梅 吴湘兰 栾静 

机构地区：[1]深圳市宝安区龙华人民医院新生儿科,广东深圳518109

出　　处：《医药论坛杂志》2011年第23期91-92,95,共3页Journal of Medical Forum

基　　金：广东省深圳市宝安区科技计划立项项目(编号:2004162)

摘　　要：目的探讨早产儿乙肝疫苗接种时机、剂量研究和远期效果评价。方法对180名早产儿进行乙肝疫苗免疫接种,通过不同接种时机、剂量来反应其检测抗-HBs阳性远期效果情况。结果 180名观察对象经过检测后,观察发现抗-HBs阳性人数为90名,检出率为50.0%,其中首次接种后第13、和6个月的抗-HBs阳转率分别为20.0%、38.3%和91.7%,逐渐增加,3个时间段前后差异都有统计学意义(P<0.05)。不同免疫后时间段的大剂量抗-HBs阳性率都明显高于小剂量(P<0.05)。结论小儿接种是预防和控制乙型肝炎的有效手段,在应用建议推迟到6个月进行免疫,多采用大剂量疫苗。Objective To investigate the t long-term effects of Hepatitis B vaccination inoculation time and dose in preterm children.Methods Totally 180 preterm children vaccinated for hepatitis B vaccine,vaccination with different timing,dose response to the detection of anti-HBs positive long-term effects of the situation.Results Totally 180 observed objects have been tested,the number of anti-HBs was 90 cases,the detection rate was 50.0%.the first species after 1 month,3 months and 6 months of anti-HBs seroconversion rates were 20.0%,38.3% and 91.7%,three time periods before and after differences are statistically significant（P0.05）.Different time periods after immunization of large doses of anti-HBs positive rate was significantly higher than low-dose（P0.05）.Conclusions The hepatitis B vaccine is the best way to prevent neonatal hepatitis B,can effectively prevent and control hepatitis B transmission.In the application to be deferred for six months for immunization,the use of high-dose vaccine.

关 键 词：重组生物酵母乙肝疫苗 早产儿 接种时机 剂量 

分 类 号：R186[医药卫生—流行病学]