电针内关穴联合丹参治疗大鼠急性心肌缺血  

The Treatment of Acute Myocardium Ischemia by using Electro-acupuncture and Danshen in Rats

作　　者：张玉英[1] 李金华[1] 

机构地区：[1]苏州大学医学部实验中心,江苏苏州215123

出　　处：《苏州大学学报（医学版）》2011年第6期927-929,983,共4页Suzhou University Journal of Medical Science

摘　　要：目的观察和比较针刺内关穴、静脉注射丹参以及两者联合应用对大鼠急性心肌缺血(AMI)不同的改善效应。方法采用SD大鼠结扎左冠状动脉前降支建立AMI模型,设立对照组、AMI组、丹参治疗组、丹参联合电针内关穴治疗组(联合组),观察各组大鼠的平均动脉压(MAP)、左心室内压(IVP)、氧分压(PO_2)、二氧化碳分压(PCO_2)、心脏NO含量。结果丹参能提高IVP、PO_2,降低PCO_2,但对血压无影响。丹参联合针刺内关穴不但能提高IVP、PO_2,降低PCO_2,而且能升高血压。丹参治疗组及联合组中心肌组织中NO的含量均有所增加。结论丹参联合针刺内关穴对AMI具有协同作用。Objective To observe and compare the different effects in treatment with electro-acupuncture （EA） at neiguan acupoint,intravenous administration of danshen and the drug administration combined with the EA in rats with acute myocardial ischemia（AMI）.Methods The rat model of AMI was set up by ligature of the anterior descending branch of the left coronary artery.The animals were divided randomly into 4 groups,i.e.the control group,the AMI group,the danshen administration group and the group of danshen combined with the EA at Neiguan acupoint.Results Danshen increased left ventricle pressures and PO_2 and decreased PCO_2,did not affect blood pressure,the combination of EA and danshen not only increased left ventricle pressures and PO_2,decreased PCO_2,but also improved mean blood pressures.Both of myocardium nitric oxide increased in the danshen and the combination groups.Conclusion The combination treatment of EA and danshen for AMI rats has synergic effects.

关 键 词：针刺 内关穴 丹参 心肌缺血 

分 类 号：R542.2[医药卫生—心血管疾病] R282[医药卫生—内科学]