毛茛总皂苷对小鼠耐缺氧及记忆能力的影响  

Effects of Total Saponins from Ranunculus japonicus Thunb.on Anti-hypoxia and Memory Ability of Mice

作　　者：秦汝兰[1] 孟庆双[1] 

机构地区：[1]通化师范学院制药与食品科学系,吉林通化134001

出　　处：《安徽农业科学》2011年第22期13404-13404,13406,共2页Journal of Anhui Agricultural Sciences

摘　　要：[目的]观察毛茛总皂苷对小鼠耐缺氧和记忆能力的影响。[方法]用不同剂量毛茛总皂苷给正常小鼠连续灌胃14 d,测定其耐缺氧时间及走迷宫试验成功次数。[结果]毛茛总皂苷高低剂量组均能延长小鼠的耐缺氧时间和增强小鼠记忆能力。[结论]毛茛总皂苷对小鼠具有益智和延长寿命的作用,具有较好的药用价值和开发前景。[Objective] To observe the effects of total saponins from Ranunculus japonicus Thunb.on anti-hypoxia and memory ability of mice.[Methods] Mice were given with different doses of total saponins from Ranunculus japonicus Thunb.by gastric perfusion for successive 14 days.Then,the anti-hypoxia time and successful times to run a maze of mice were respectively determined.[Result] Mice treated with low-dose and high-dose total saponins from Ranunculus japonicus Thunb.could significantly prolong anti-hypoxia time and improve memory ability.[Conclusion] The total saponins from Ranunculus japonicus Thunb.could obviously promote intelligence development and prolong life of mice with high medical value and good development prospect.

关 键 词：毛茛(Ranunculus JAPONICUS Thunb.) 总皂苷 耐缺氧 记忆力 

分 类 号：S567.23[农业科学—中草药栽培]