儿茶酚氧位甲基转移酶基因多态性与糖尿病伴抑郁的相关性研究  

Association of polymorphism of catechol-o-methyltransferase with depression in patients with type 2 diabetes

作　　者：曹音[1] 刘广军[2] 成金罗[3] 杨科春[3] 袁勇贵[4] 

机构地区：[1]南京医科大学附属常州第二人民医院神经内科,常州213000 [2]南京医科大学附属常州第二人民医院药剂科,常州213000 [3]南京医科大学附属常州第二人民医院内分泌科,常州213000 [4]东南大学附属中大医院

出　　处：《中国糖尿病杂志》2012年第1期24-27,共4页Chinese Journal of Diabetes

基　　金：江苏省卫生厅基金项目(200707)

摘　　要：目的探讨儿茶酚氧位甲基转移酶(COMT)Val 158Met多态性与糖尿病伴抑郁的关联研究。方法用聚合酶链反应及聚丙烯酰胺凝胶电泳方法,检测246例糖尿病患者和186名健康体检者(对照组)的COMT基因Val 158 Met多态性。用汉密尔顿抑郁量表(HAMD)评定所有糖尿病患者,HAMD≥17分者为糖尿病伴抑郁组,HAMD<7分为糖尿病不伴抑郁组。结果糖尿病伴抑郁组、糖尿病不伴抑郁组的G等位基因和基因型G/G频率均高于对照组,A等位基因和基因型G/A频率低于对照组(P<0.05)。糖尿病不伴抑郁组中,男性基因型A/A分布频率显著高于女性。糖尿病伴抑郁组中,男性比率显著低于女性。结论 COMT基因Val 158Met多态性与糖尿病伴抑郁症可能存在相关性;男性糖尿病患者较女性可能不易伴发抑郁。Objective To study the association of polymorphism of catechol-o-methyltransferase with depression in patients with type 2 diabetes. Methods Using a polymerase chain reaction,val158met polymorphism of COMT was determined in 246 type 2 diabetes and 186 health control subjects.All of patients with type 2 diabetes received HAMD scoring.HAMD rating scale ≥17 represented depression;and 7,no depression. Results Allele G and genotype GG frequencies were higher in T2DM both with and without depression group than in control group（all P〈0.05） and A allele and G/A genotype frequencies were lower in T2DM both with and without depression group than in control group.A/A genotype frequency was higher in male than in female in T2DM without depression（P〈0.05）.Prevaleuce of T2DM plus depression was lower in male than in female（P〈0.05）. Conclusion（1）The polymorphism of COMT gene val158met associates with type 2 diabetes plus depression.（2） Male patients with type 2 diabetes show less incident depression than female patients with type 2 diabetes.

关 键 词：儿茶酚氧位甲基转移酶 糖尿病 2型 抑郁 

分 类 号：R587.1[医药卫生—内分泌] R749.2[医药卫生—内科学]