2型糖尿病及其微血管并发症患者血浆抵抗素和趋化素的变化和相关因素观察  

Observation of the correlation of changes in serum Resistin and Chemerin with relative factors in patients with type 2 diabetes and diabetic microvascular complications

作　　者：吴卫平[1] 房辉[1] 田金莉[1] 张雅中[1] 张禾伟[1] 许静[1] 

机构地区：[1]唐山工人医院内分泌科,河北唐山063000

出　　处：《中国糖尿病杂志》2012年第1期55-57,共3页Chinese Journal of Diabetes

摘　　要：目的研究抵抗素(Resistin)和趋化素(Chemerin)在新诊断的T2DM及T2DM合并微血管并发症(T2DM+MC)患者血浆中表达水平,探讨二者在T2DM及T2DM+MC发病中的作用。方法新诊断的T2DM患者、T2DM+MC患者各50例,健康对照(NC)50名,各组再根据BMI分为肥胖组和非肥胖组,比较各组血浆Resistin和Chemerin水平。结果新诊断的T2DM组、T2DM+MC组Resistin分别为(24.3±4.1)ng/ml,(29.7±3.6)ng/ml,明显高于NC组的(17.1±1.9)ng/ml;Chemerin分别为(109.7±24.3)pg/ml,(115.3±34.7)pg/ml,明显高于NC组的(78.4±31.4)pg/ml(P<0.01)。新诊断的T2DM组及T2DM+MC组的肥胖亚组Resistin和Chemerin均明显高于非肥胖亚组(P<0.05)。各组女性患者Resistin和Chemerin水平均显著高于男性患者(P<0.05)。结论新诊断的T2DM和T2DM+MC组血浆Resis-tin及Chemerin水平较NC组显著升高。Resistin及Chemerin水平受性别、脂肪分布的影响。与新诊断的T2DM患者比较,T2DM+MC组血浆Resistin及Chemerin水平呈升高趋势,但未显示统计学差异。Objective To research the correlation of changes of serum Resistin and Chemerin with relative factors in both type 2 diabetes and type 2 diabetic micro-angiopathy. Method This, study included 50 newly diagnosed T2DM patients （T2DM）, 50 T2DM patients with microvascular complications （MC）, and 50 normal healthy subjects （NC）. The patients were divided into obese groups and non-obese group~ Plasma Resistin and Chemerin level were measured. Results The Resistin level was higher in T2DM [（24. 3±4. 1）ng/ml] and T2DM plus MC [（29.7±3.6） ng/ml]group than in NC [（17.1±1.9） ng/ml] group （P〈0. 05）. The Chemerin leVel was higher in T2DM 1-（109.7±24.3）pg/ ml] and T2DM plus MC [-（115.3±34. 7） pg/ml3 group than in NC [-（78.4±31.4） pg/ml3 group （P〈 0. 01）. Obesity subgroup versus non-obesity subgroup showed significantly higher levels of both Resistin and Chemerin in both T2DM group and T2DM plus MC group （all P^0. 05 or 0. 01）. Female versus male showed a significantly higher level of Chemerin in T2DM, T2DM plus MC and NC group, and a higher level of Resistin only in T2DMWMC group and NC group （all P〈0. 05）, but not in T2DM group （P〈 0. 05）. Concision The levels of Resistin and Chemerin are higher in T2DM and T2DM plus diabetic microvascular complication groups than in normal control group. Female and obesity show a increased level of Resistin and Chemerin in normal control and T2DM.

关 键 词：糖尿病 2型 微血管并发症 RESISTIN CHEMERIN 胰岛素抵抗 

分 类 号：R587.2[医药卫生—内分泌]