甘草黄酮对2型糖尿病大鼠血糖、血脂等生化指标的影响  

Effect of licorice flavonoids on blood glucose,blood lipid and other biochemical indicators in type 2 diabetic rats

作　　者：赵海燕[1] 王勇[1] 吴力武[1] 马永平[1] 

机构地区：[1]北方民族大学生物科学与工程学院,银川750021

出　　处：《中国糖尿病杂志》2012年第1期65-69,共5页Chinese Journal of Diabetes

基　　金：教育部留学回国人员科研启动基金资助项目(2005年)

摘　　要：目的研究甘草黄酮(LF)对T2DM大鼠血糖、血脂等生化指标的影响。方法将实验大鼠分为模型组(DM)、高剂量给药组(HLF)、低剂量给药组(LLF)、正常对照组(Con)和正常给药组(CLF)。分别以LF或溶剂灌胃,5周后检测实验大鼠的空腹血糖、血脂等生化指标及肝体比、肾体比和脂体比。结果高剂量LF(300mg.kg-1.d-1)显著降低了糖尿病大鼠的FBG、TG、TC、LDL-C、FFA、TNF-α、瘦素、肝体比和肾体比,并显著提高了糖尿病大鼠的T-AOC、ISI和脂体比。结论 LF具有降低糖尿病大鼠血糖、调节脂代谢紊乱的作用,并可显著改善胰岛素抵抗。Objective To study the effect of licorice flavonoids（LF） on fasting blood levels of glucose（FBG）,lipids,insulin,adipokines and other biochemical indicators. Methods The type 2 diabetic rat model was replicated by feeding high-fat and high-sugar diet combined with low-dose streptozotocin（STZ） injection.The diabetic rats were divided into model group（DM）,high-dose LF treatment group（HLF） and low-dose LF treatment group（LLF）.Other 20 normal rats were divided into control group（Con） and control treatment group（CLF）.Rats in different groups were administered LF（100mg or 300mg·kg^-1·d^-1） or solvent（propylene glycol） respectively.Five weeks later,the levels of fasting levels of glucose（FBG）,triglycerides（TG）,total cholesterol（TC）,free fatty acids（FFA）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,total antioxidation capability（T-AOC）,insulin（Ins）,tumor necrosis factor alpha（TNF-α） and leptin were examined.Insulin sensitivity index（ISI）,liver index,kidney index and the relative weight of abdominal adipose tissue were calculated. Results The high-dose LF（300mg·kg-1·d-1） treatment significantly decreased the levels of FBG,TG,TC,LDL-C,FFA,T-AOC,TNF-α,leptin,liver index and kidney index,and increased the levels of T-AOC,ISI and the relative weight of abdominal adipose tissue.Compared with high-dose treatment,low dose of LF was less effective. Conclusion LF significantly decreases the blood glucose level,improves the lipid metabolic disorders and ameliorates insulin resistance in type 2 diabetic rats.

关 键 词：甘草黄酮 糖尿病 2型 胰岛素抵抗 血糖 血脂 

分 类 号：R587.1[医药卫生—内分泌]