妊娠妇女骨钙素变化原因与临床意义  

Clinecal significance on the change of bone glutamate protein (BGP)in pregnant women.

作　　者：王晓雯[1] 陈伟[1] 

机构地区：[1]山东省淄博市妇幼保健院放免室,255029

出　　处：《中国优生与遗传杂志》2000年第1期62-62,共1页Chinese Journal of Birth Health & Heredity

摘　　要：骨钙素（ＢＧＰ） 是反映骨转换的一个特异、灵敏的生化指标，它反映了骨形成瞬间的改变及代谢性生理及病理变化。通过进行及早的预防和治疗，以保障母婴健康。应用ＲＩＡ 法测量ＢＧＰ。结果：与正常对照组相比，不同孕期ＢＧＰ均有所下降，孕中期有显著性差异（Ｐ＜ ０－０１） ，孕晚期ＢＧＰ又增加，与正常对照无显著性差异，但与孕中期相比，有显著性差异（Ｐ＜０－０５） 。我们认为，测定不同孕期的ＢＧＰ可预测其病理改变程度，从而有效地改善孕期妇女的健康，提高胎儿的生存质量。BGP is a specific and sensitive biochemical indictor in skeleton transformation,which can mirror the immediate changes of skeletogeny and phsiological and pathological changes of metabolism.Method:By measuring the value of BGP in gestational perod,we can take prophylactic action against possible diseases in this period and treat them at an early stage,so as to safeguard both mothers and infants.RIA was employed in this experiment.Result:compared with the control group,the values of BGP declined graduallv with the duration of gestational period in different gestation groups. reaching the lowest level in the medium?term (midferimester)with significant difference(P<0.01).The values of BPG increased in the early pregnancy,which showed no difference compared with control,but had a significant difference with those of midtrimeser (P<0.05).Conclusion:the prophylactic measurement can be taken against diseases according to the values of BGP during different periods of gestation,which will in turn improve health condition of the pregnant women and enhance the quality of the newborns.

关 键 词：骨钙素 妊娠妇女 骨转换 病理变化 

分 类 号：R714.1[医药卫生—妇产科学]