随机单次测定血清孕酮、雌二醇对异位妊娠早期诊断的应用价值  

The Clinical Value of Single Random Measurement of Serum Progesterone and Estradiol for Early Diagnosis of Ectopic Pregnancy

作　　者：宋殿荣[1] 钱丽娟[1] 翟瞻粲 刘桂敏[2] 

机构地区：[1]天津医科大学第二医院妇产科,300211 [2]天津医科大学第二医院同位素科,300211

出　　处：《天津医药》2000年第2期74-76,共3页Tianjin Medical Journal

摘　　要：目的:在常规诊断方法的基础上,测定血清孕酮(P)和雌二醇(E_2),探讨对异位妊娠的早期诊断及其与正常宫内妊娠和异常宫内妊娠的鉴别诊断价值。方法:对象以可疑异位妊娠病人为观察组,正常宫内妊娠及异常宫内妊娠分别作为对照组,3组孕周均不超过8周。单次取血利用放免法测定血清P和E_2。结果:异位妊娠的P和E_2水平显著低于正常宫内妊娠和先兆流产孕妇(P<0.01)。既往常规诊断方法对异位妊娠诊断的敏感性、特异性分别为66.67%、85.71%,而参考P、E_2的第5百分位数诊断异位妊娠的敏感性分别为93.33%和91.11%,特异性分别为92.00%和98.00%。结论:对就诊较早的可疑异位妊娠病人,常规诊断方法参考随机单次取血测定的血清P、E_2水平,对早期诊断异位妊娠有重要应用价值。Objective: Assaying of serum progesterone and estradiol in addition to routine diagnosis methods for early differential di-agnosis of ectopic pregnancy and normal and abnormal intrauterine pregnancies. Methods:Suspicious ectopic pregnancies who received medical treatment were selected as experimental group, normal and abnormal intrauterine pregnancies as control groups. Their gestation age was no more than eight weeks. Progesterone and estradiol were measured with radioimmunoas-say.Results: Serum progesterone and estradial levels were dramatically lower than those of normal intrauterine pregnancies and threatened abortions (P<0.01). Routine diagnostic sensitivity and specificity of ectopic pregnancy were 66.7% and 85.71% respectively. With reference to the fifth percentile of serum progesterone and estradiol, the diagnostic sensitivity turned out to be 93.33% and 91.11% respectively,and the specificity 92.00% and 98.00% respectively.Conclusion:The research suggested that to combine with routine diagnosis for suspicious ectopic pregnancy, the reference to a single random measurement of serum progesterone and estradiol was of great application value for early differential diagnosis of ectopic pregnancy.

关 键 词：孕酮 雌二醇 异位妊娠 诊断 血清 

分 类 号：R714.220.4[医药卫生—妇产科学]