多环芳烃类混合物接触者血清P21水平的追踪研究  

Follow-up study on the serum P21 level in workers exposed to polycyclic aromatic hydrocarbons(PAHs)

作　　者：吴逸明[1] 王新朝[1] 贾定武[1] 陈琛[1] 许东[1] 李时恩[1] 冯文德 肖文[2] 

机构地区：[1]河南医科大学劳动卫生学教研室,450052 [2]河南省安阳市职业病防治所

出　　处：《中华劳动卫生职业病杂志》2000年第1期49-50,共2页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：目的　了解P2 1对职业性肺癌的预报价值。方法　用WesternBlotting免疫印迹法对2 0名沥青工、焦炉工和 12名对照者血清P2 1水平进行了追踪观察。结果　 2 0名沥青工、焦炉工的血清P2 1水平有上下波动现象 ;他们的第 2次P2 1检测值 (3773.3± 10 33.7)高于第 1次 (34 84.4±1915 .8) ,但差异无显著性 (P >0 .0 5 ) ;接触组的这两次P2 1检测值 (34 84.4± 1915 .8、3773.3±10 33.7)始终高于对照组 (1199.8± 75 7.3、12 70 .7± 6 34 .7) ,差异有显著性 (P <0 .0 1)。结论　多环芳烃类混合物具有较强的遗传毒性 ,可使职业工人在早期接触阶段出现P2 1的高表达。Objective To explore the role of P21 in predication of occupational lung cancer. Methods Serum P21 levels from 20 workers exposed to coal tar pitch(CTP) and to coke oven volatiles(COV) and from 12 cases of normal controls were longitudinally studied with the method of Western Blotting. Results It was found that some individual P21 went up and the others went down.P21 level in the exposed workers detected at the second time (3 773.3± 1 033.7) was not significantly different from that at the first time (3 484.4± 1 915.8, P >0.05).P21 levels in exposure group(3 484.4±1 915.8, 3 773.3± 1 033.7 respectively) were significantly higher than that in control (1 199.8± 757.3, 1 270.7± 634.7 respectively). Conclusion Polycyclic aromatic hydrocarbons(PAHs) has a strong genetic toxic effect and can cause P21 level increase in earlier stage among occupational workers.

关 键 词：血清P21 职业接触 多环芳烃 PAHS 肺癌 

分 类 号：R135.1[医药卫生—劳动卫生]