聚谷氨酸苄酯与丙烯酰胺共聚物的制备与性能研究  

Synthesis and characterization of poly (γ-benzyl-L-glutamate)/polyacrylamide copolymer

作　　者：魏来[1] 胡国胜[1] 周秀苗[1] 

机构地区：[1]中北大学高分子与生物工程研究所,山西太原030051

出　　处：《功能材料》2011年第2期310-312,317,共4页Journal of Functional Materials

基　　金：国家重点基础研究发展计划(973计划)资助项目(2005CB623902);中北大学校基金

摘　　要：用烯丙基胺引发γ-苄酯-L-谷氨酸-N-羧酸酐(Bz-L-Glu-NCA)开环聚合得到了端烯丙基的聚谷氨酸苄酯(A-PBLG),A-PBLG不仅具有聚谷氨酸苄酯良好的生物相容性及降解产物无毒等优点,还拥有了可与药物或者其它基体材料可反应的功能基团。采用紫外光聚合法将亲水性能良好的丙烯酰胺(AM)引入A-PBLG制备出两亲性的聚谷氨酸苄酯/丙烯酰胺共聚物(PBLG-AM),并对PBLG-AM的结构和性能进行研究。结果表明,PBLG-AM的亲水性和降解性能较A-PBLG得到明显的提高。Allyl-terminated poly（γ-benzyl-L-glutamate）（A-PBLG） was successfully synthesized by the anion ring-opening polymerization of N-carboxy-γ-benzyl-L-glutamate anhydride（Bz-L-Glu-NCA） initiated by allylamine.A-PBLG have many advantages such as good biocompatibility and innocuity of degradation products and having the functional group（allyl） that improves its biomedical application.Acrylamide with good hydrophility was copolymerized with A-PBLG through photo-induced polymerization and amphophilic PBLG-AM was successfully prepared.Structure and property was fully characterized.Results indicated that the hydrophility and biodegradation property of PBLG-AM was improved.

关 键 词：聚谷氨酸苄酯 丙烯酰胺 两亲性 

分 类 号：TQ316.341[化学工程—高聚物工业]