环氧乙烷对小鼠脊髓神经细胞膜上嵌入蛋白质分布的影响  

EFFECTS OF ETHYLENE OXIDE ON DISTRIBUTION OF INSERTING PROTEINS ON NERVE CELL MEMBRANE OF SPINAL CORD IN MICE

作　　者：陈光忠[1] 夏国兴[1] 陆静芬[1] 钟坤[1] 张龄[1] 

机构地区：[1]上海职工医学院解剖学教研室,上海200237

出　　处：《解剖学杂志》2000年第1期87-89,共3页Chinese Journal of Anatomy

基　　金：国家自然科学基金资助!(编号39070477)

摘　　要：目的：研究环氧乙烷对小鼠神经细胞膜上嵌入蛋白质分布的影响。方法：小鼠每天吸入环氧乙烷２ｈ，持续２或３个月，用冰冻蚀刻电镜观察小鼠腰髓前角神经细胞膜上嵌入蛋白质的分布。结果：随着染毒时间延长，腰髓前角神经细胞膜上的嵌入蛋白质由分布紊乱至成簇聚集。结论：环氧乙烷能改变神经细胞膜上嵌入蛋白质的分布。To study effects of ethylene oxide on the distribution of inserting proteins in nerve cell membrane of mice. Methods: The mice were inhaled ethylene oxide for 2 hours every day. After 2 or 3 months, scanning electron microscope with freeze etching was used to observe the distribution of inserting proteins in nerve cell membrane of anterior horn in spinal cord of mice. Results: as the extending of inhaling time inserting proteins distribution changed from turbulence to cluster. Conclusion: Ethylene oxide can change the distribution of inserting proteins in nerve cell membrane.

关 键 词：脊髓 神经细胞 细胞膜 嵌入蛋白质 环氧乙烷 

分 类 号：R994[医药卫生—毒理学]