PPAR-γ对卵巢功能的影响及其作用机制  

Roles of PPAR-γ in the Ovarian Function and Its Involved Mechanisms

作　　者：匡志超[1,2] 王健[2] 孙兆贵[2] 

机构地区：[1]复旦大学上海医学院,上海200032 [2]上海市计划生育科学研究所,国家人口和计划生育委员会计划生育药具重点实验室,上海200032

出　　处：《生殖与避孕》2012年第1期42-48,共7页Reproduction and Contraception

基　　金：国家自然基金(81070490,81170569);上海市科学技术委员会项目(10140901900和10140901502)资助

摘　　要：过氧化物酶体增殖剂激活受体(peroxisome proliferator-activated receptors,PPARs)是配体依赖型核受体,目前发现PPARs具有多种亚型,包括有PPAR-α、PPAR-β和PPAR-γ等,其中对PPAR-γ的研究最为深入。PPAR-γ在细胞信号转导中起重要作用,参与调节细胞内许多功能,如脂肪细胞分化、脂质代谢、免疫细胞活化和炎症介质生成等。近年来的一些研究也显示,PPAR-γ在卵巢组织周期性调控中也发挥着重要的作用,如促进排卵等。在卵巢组织中,PPAR-γ可由卵巢组织自身产生,并参与调控卵巢的周期性变化;同时,脂肪或巨噬细胞中激活的PPAR-γ可能通过脂质代谢或炎症介导因子而对卵巢产生重要影响。The peroxisome proliferator-activated receptor（PPAR） is a ligand-dependent nuclear receptor,and it has a variety of subtypes,including PPAR-a,PPAR-b and PPAR-γ,etc.,in which studies on PPAR-γ are the most advanced.PPAR-γ signal transduction in cells plays an important role in regulating many cellular functions,such as adipocyte differentiation,lipid metabolism,immune cell activation,and inflammatory mediator generation,and so on.Some recent studies have also shown that PPAR-γ also plays an important role in the regulation of the ovarian cycle,such as in promoting ovulation.Not only PPAR-γ from fat tissues and macrophages may have important impacts on the ovary through signal pathways of lipid metabolism or by inflammatory factors in the activation of macrophages,but also PPAR-γ originated from the ovarian tissues possibly induce the cyclical changes in the ovary.This article focuses on the PPAR-γ activation and the relationship between women＇s reproductive capacity.

关 键 词：PPAR-Γ 生育能力 糖脂代谢 免疫调节 

分 类 号：R339.2[医药卫生—人体生理学]