纳米金检测单核苷酸多态性的应用进展  

Gold nanoparticles for the detection of single nucleotide polymorphism:An update

作　　者：孙加司[1] 陈思娇[2] 史记[2] 邵义[3] 宋今丹[4] 

机构地区：[1]中国医科大学 [2]中国医科大学第一医院干部医疗工作部,沈阳110001 [3]沈阳工业大学材料科学与工程学院,沈阳110870 [4]卫生部教育部细胞生物学重点实验室中国医科大学医学分子生物学研究所,沈阳110001

出　　处：《医学研究生学报》2012年第1期85-88,共4页Journal of Medical Postgraduates

基　　金：辽宁省教育厅项目(2008818-05L303);辽宁省自然科学基金(20062044)

摘　　要：单核苷酸多态性(single nucleoride polymorphism,SNP)与疾病发生的关系的重要性日益受到重视,探讨SNP与各种疾病发生的相关性研究已见于大量报道。传统的检测SNP的方法操作复杂,费时费力,假阳性高,新的SNP检测方法不断出现并应用。纳米金法是目前较为成熟的检测技术,文中介绍几种常见的SNP检测方法。More and more importance is being attached to the association of single nucleotide polymorphism（SNP） with the development of diseases,and more and more studies have been reported on their correlation.Traditional methods for SNP detection are complicated,cost much time and labor,and give a high false positive rate.New methods have been constantly developed and applied,among which detection with gold nanoparticles is one of the relatively mature techniques.This article introduces several typical SNP detection methods,aiming to provide some ideas and reference for further studies.

关 键 词：纳米金 单核苷酸多态性 

分 类 号：Q524.3[生物学—生物化学]