老年人髋关节置换术后认知功能障碍的研究  

Study on postoperative cognitive dyfunction in elderly patients undergoing hip joint replacement

作　　者：付春梅[1,2] 杨少辉[1,2] 黄明理[1,2] 关世平[1,2] 万绵熔[1,2] 

机构地区：[1]汕头潮南民生医院 [2]汕头大学医学院第一附属医院,515144

出　　处：《中国实用医药》2011年第36期28-29,共2页China Practical Medicine

摘　　要：目的探明咪达唑仑对于髋关节置换手术老年患者术后认知功能(POCD)的影响。方法择期髋关节置换手术患者30例,年龄65～89岁,随机分成2组(n=30):对照组和咪达唑仑组。对照组术中不用镇静镇痛药,咪达唑仑组术中给予咪达唑仑2～4mg。两组于术前1d、术后1d、3d记录简易智能状态检查法(MMSE)评估患者认知功能。结果与术前比较,咪达唑仑组术后第1天MMSE评分降低(P<0.05),而对照组术后第1天、第3天与术前比较MMSE评分比较差异无统计学意义(P>0.05);2组间MMSE评分比较差异无统计学意义(P>0.05)。结论咪达唑仑对于老年患者术后早期POCD有一定影响。Objective To investigate the effect of midazolam on cognitive function undergoing hip joint replacement in the elderly.Methods Thirty ASAⅠor Ⅱ patients aged 65～89 years undergoing hip joint replacement were randomly divided into 2 groups（n=15 each）：control group and midazolam group.In midazolam group 2～4 mg midazolam was injected into vein during operative.In control group the sedatives or the narcotics were not used.The Mini-mental state examination（MMSE） was useded to assess congnitive funtion 1 d before surgery and 1 d and 3 d after surgery.Results The MMES scores in 1 d after operation was significantly lower than in 1 d before operation in midazolam group.The MMES scores in 1 d and 3 d after operation were not significantly different from the MMES scores in 1 d before operation in control group.There were no significant difference the MMES scores between the 2 groups.Conclusion The midazolam has some influence on early postoperative cognitive function in elderly patients undergoing hip joint replacement.

关 键 词：术后认知功能障碍 髋关节置换手术 老年人 MMSE评分 简易智能状态检查 咪达唑仑 老年患者 镇静镇痛药 

分 类 号：R687.4[医药卫生—骨科学]