胱抑素C与急性冠脉综合征的相关性分析  

Association of Plasma Cystatin C Level and Acute Coronary Syndrome

作　　者：刘玉[1] 刘俊[1] 陶春明[1] 周利民[1] 

机构地区：[1]安徽医科大学滁州临床学院心内科,安徽省滁州市239000

出　　处：《中华全科医学》2012年第2期208-208,244,共2页Chinese Journal of General Practice

摘　　要：目的探讨冠心病患者血清胱抑素C(Cystatin C,Cys C)水平与急性冠脉综合征(ACS)的相关性及其临床意义。方法选择经冠状动脉造影检查的患者共132例,冠心病的诊断标准为冠状动脉造影证实至少有一支心外膜血管直径狭窄≥50%,并结合心电图、心肌酶学等检查结果分为对照组(30例)、稳定型心绞痛组(SAP,34例)、不稳定型心绞痛组(UA,35例)和急性心肌梗死组(AMI,33例)4组,采用免疫比浊法(IMT)检测血清Cys C的浓度。结果①各组间患者的年龄、性别、吸烟、高血压、糖尿病、高血脂等比较差异无统计学意义(P>0.05)。②各组间HsCRP比较,UA高于对照组和SAP,同时AMI明显高于对照组和SAP;各组间Cys C水平比较,差异有统计学意义(F=5.668,P值=0.002),其中UA高于对照组和SAP,AMI低于对照组和SAP。结论冠心病患者血清Cys C水平在ACS分层中有指导意义。Objective To investigate the level of plasma Cystatin C,and to evaluate the relationship between plasma Cystatin C level and acute coronary syndrome.Methods A total of 132 consecutive patients with coronary artery disease（CAD） were selected by coronary angiography,consisting of 34 patients with stable angina pectoris（SAP）,35 patients with unstable angina pectoris（UA）,33 patients with acute myocardial infarction（AMI）,and 30 healthy subjects as controls.The diagnostic criteria for CHD was that there was at least one epicardial vessel with the diameter stenosis≥50% by coronary angiography.In this study,plasma Cystatin C was measured by immunoturbidimetry（ITM）.Results ①There were not statistical differences in age,sex,smoking,hypertension,diabetes and hyperlipidemia in each group（P0.05）.②Much higher HsCRP concentrations were found in UA patients and AMI patients（P=0.009）.Cystatin C levels were significantly higher in UA patients than those in SAP patients and controls,but AMI patients were much lower than those in SAP patients and controls（F=5.668,P=0.002）.Conclusion Cystatin C played an important role in the development of CAD and plasma Cystatin C was a strong predictor for risk of cardiovascular events.

关 键 词：冠心病 急性冠脉综合征 胱抑素C 

分 类 号：R541.4[医药卫生—心血管疾病]