铬作业工人尿γ-谷氨酰移换酶活性的研究  

An investigation on urinary γ-GT activities in workers occupationally exposed to chromate.

作　　者：郭卫星[1] 王翔朴[1] 何兴轩[1] 梁绍先[1] 

机构地区：[1]湖南医科大学环境医学研究室

出　　处：《职业医学》1990年第1期7-8,63,共2页China Occupational Medicine

基　　金：国家自然科学基金

摘　　要：本文对47名铬作业工人的肾功能状况进行了研究。结果表明γ-GT活性增加是反映铬中毒性肾损害的敏感指标之一。尿γ-GT活性与尿铬、尿蛋白和β_2-MG含量呈显著性相关。因此,尿γ-GT活性检测可作为铬性肾损害的监测指标。47 workers exposed to chromate were studied on their renal functions. The results showed that the changes of γ-GT in urine was one of the sensitive indicators reflecting toxic renal damage due to chromium. There were significant correlations among the activities of urinary γ-GT and the contents of chromium, protein, or β_2-MG in urine. Therefore, urinary γ-GT may be used as an indicator of detecting toxic renal damage due to chromium.

关 键 词：铬 肾 尿酶 肾脏毒性 

分 类 号：R598.1[医药卫生—内科学]