RGD功能化HA/PLLA多孔复合材料的制备和表征  

Preparation and Characterization of RGD-HA/PLLA Porous Composite

作　　者：杨春莉[1] 杨春瑜[2] 盖艳娇[1] 赵智臻[3] 刘壮[1] 王君[1] 

机构地区：[1]哈尔滨商业大学轻工学院,哈尔滨150076 [2]哈尔滨商业大学食品工程学院,哈尔滨150076 [3]厦门大学化学化工学院,厦门361005

出　　处：《机械工程材料》2012年第1期45-47,61,共4页Materials For Mechanical Engineering

基　　金：黑龙江省科技厅青年科学基金资助项目(Q07C308)

摘　　要：通过碳二亚胺法将精氨酸-甘氨酸-天冬氨酸(RGD)接枝到羟基磷灰石(HA)颗粒表面,增强HA颗粒识别细胞的功能,然后将其均匀地分布于左旋聚乳酸(PLLA)中制备多孔复合材料,分别用XPS和SEM等对HA颗粒和多孔复合材料进行了表征。结果表明:RGD成功地接枝到了HA颗粒表面,多孔复合材料中RGD功能化的HA颗粒是纳米尺寸的,且分布均匀;RGD功能化HA/PLLA多孔复合材料的细胞粘附率从普通HA/PLLA多孔复合材料的37.21%提高到了69.11%。RGD was grafted on HA particle surface by carbodiimide method to increase the cell recognizing function of HA particles,and then the particles were homogenously distributed in PLLA to prepare porous composite.HA particles and porous composite were characterized by XPS and SEM.The results show that RGD was successfully grafted on HA particle surface,RGD-HA particles were nano-size and homogenously distributed in the porous composite.Cell adhesive ratio of RGD-HA/PLLA porous composite increased from 37.21% of ordinary PLLA/HA to 69.11%.

关 键 词：精氨酸-甘氨酸-天冬氨酸(RGD) 羟基磷灰石(HA) 左旋聚乳酸(PLLA) 多孔复合材料 

分 类 号：TH117.3[机械工程—机械设计及理论]