Handheld optical coherence tomography device for photodynamic therapy  

作　　者：WANG TianShi WANG ChengMing HUANG NaiYan ZHANG Jian GU Ying XUE Ping 

机构地区：[1]State Key Laboratory of Low-dimensional Quantum Physics and Laboratory of Atomic and Molecular Nanosciences,Department of Physics,Tsinghua University,Beijing 100084,China [2]Department of Laser Medicine,Chinese PLA General Hospital,Beijing 100853,China [3]School of Electronic Engineering,Tianjin University of Technology and Education,Tianjin 300222,China

出　　处：《Chinese Science Bulletin》2012年第5期450-454,共5页

基　　金：supported in part by the National High-Tech Research and Development Program of China (2006AA02Z472);National Basic Research Program of China (001CB510307 and 2009CB929400);National Natural Science Foundation of China (90508001, 10676014 and 10574081);Tsinghua University Initiative Scientific Research Program

摘　　要：Photodynamic therapy (PDT) is a very effective treatment for port wine stains (PWS). To guide and assess PDT treatment, a handheld optical coherence tomography (OCT) probe was designed for real-time imaging of the PWS patient. The system uses a light source with a center wavelength of 1310 nm, -3 dB bandwidth of 90 nm and an optical power of 9 mW. The system also has a spatial resolution of 8 μm (lateral) × 7 μm (axial), an imaging rate of 4 frames per second, and a 102 dB sensitivity. We then demonstrate that the OCT imaging system can clearly distinguish between normal and PWS tissues. Therefore, the system can provide valuable guidance for PDT treatment.Photodynamic therapy （PDT） is a very effective treatment for port wine stains （PWS）. To guide and assess PDT treatment, a handheld optical coherence tomography （OCT） probe was designed for real-time imaging of the PWS patient. The system uses a light source with a center wavelength of 1310 nm, -3 dB bandwidth of 90 nm and an optical power of 9 mW. The system also has a spatial resolution of 8 μm （lateral）× 7μm （axial）, an imaging rate of 4 frames per second, and a 102 dB sensitivity. We then demonstrate that the OCT imaging system can clearly distinguish between normal and PWS tissues. Therefore, the system can provide valuable guidance for PDT treatment.

关 键 词：光动力疗法 光学相干 断层扫描 扫描装置 手持式 成像系统 实时成像 空间分辨率 

分 类 号：TP334[自动化与计算机技术—计算机系统结构] TQ463[自动化与计算机技术—计算机科学与技术]