强化剂量与标准剂量他汀类药物联合治疗和控油饮食对择期PCI术后血脂水平的影响  

Effect of combined therapy of strengthening-dose and standard-dose statins with oil-controlling diet on blood lipid levels in patients after elective PCI

作　　者：孟淑萍[1] 赵军峰[1] 贾建英[1] 侯文生[1] 王志慧[1] 刘会敏[1] 柳君[1] 

机构地区：[1]冀中能源峰峰集团总医院北院区心内科,河北省邯郸市056201

出　　处：《河北医药》2012年第1期19-21,共3页Hebei Medical Journal

摘　　要：目的观察择期经皮冠脉介入(PCI)术后强化剂量与标准剂量他汀类药物联合治疗和控油饮食对血脂水平的影响的效果。方法选择择期PCI患者308例,按照是否实施控制油脂摄入分为控油组134例和非控油组174例,2组均给予术后1个月强化剂量他汀类药物及术后1个月后再调整为标准剂量他汀类药物。观察术前、术后1、3和6个月血脂变化,并进行多重线性回归分析。结果与术前比较,2组术后1个月TC和LDL-C明显下降(P<0.05)。与非控油组比较,控油组患者术后1个月LDL-C和TC变化值更高(P<0.05或<0.01)。控制油脂摄入者LDL-C下降幅度高于未控油脂摄入,2组相差0.84mmol/L(P=0.004);女性较男性LDL-C下降明显,相差0.74mmol/L(P=0.045)。结论择期PCI患者应用强化剂量与标准剂量他汀类药物联合治疗,即增加了降脂疗效,同时又能减少长期强化调脂带来的额外不良反应。此方法安全、疗效显著,实行控油措施可进一步降低LDL-C,控油措施是血脂水平调控的重要影响因素。Objective To observe the effect of combined therapy of strengthening-dose and standard-dose statins with oil-controlling diet on blood lipid levels in patients after elective percutaneous coronary intervention （PCI）. Methods The 308 patients who underwent elective PCI were divided into two groups,oil-controlling group （n = 134 ） and non oil-controlling group （n = 174 ）, and the patients in both groups were treated by strengthening-dose statins during the first month after PCI, then they were treated by standard-dose statins. The changes of blood lipid levels before PCI and at 1,3,6 months after the surgery were observed for both groups,and multiple linear regression analysis was performed. Results As compared with the baseline, the levels of TC and LDL-C were significantly decreased at 1 month after the surgery for both groups （ P 〈 0.05）. The changes of TC and LDL-C levels were more obvious in oil-controlling group than those in non oil-controlling group （ P 〈 0.05 or 〈0.01 ）. Multiple linear regression analysis showed that the reduction extent of LDL-C levels in oil-controlling group were more obvious than that in non oil-controlling group,with the difference being 0.84mmol/L between the two groups （ P 〈 0.01 ）, which in females was more obvious than that in males,with difference being 0.74mmol/L （ P 〈 0.05 ）, Conclusion The combined therapy of strengthening-dose and standard-dose statins for patients undergoing elective PCI can not only enhance the efficiency of reducing blood lipid, but also can decrease side effects. So the method is safe and effective for patients undergoing elective PCI, and oil controlling measure plays an important role in the regulation of blood lipid levels.

关 键 词：不同剂量联合降血脂 药物剂量 膳食和运动疗法 血脂异常 油类 急性冠脉综合征 

分 类 号：R543.31[医药卫生—心血管疾病]