职业性铅接触者生物学效应分析  

Study of biological effect among lead exposed workers.

作　　者：许东[1] 陈琛[1] 杨廷璋 李志远[1] 姚武[1] 赵一波 李灵宏 马玉英 徐玉宝[1] 

机构地区：[1]河南医科大学

出　　处：《职业医学》1990年第5期263-265,319,共3页China Occupational Medicine

摘　　要：对蓄电池厂铅作业工人的检测结果表明:铅接触者除出现卟啉代谢障碍、幼稚红细胞增多外,染色体畸变率亦高于对照组;红细胞游离原卟啉和染色体畸变在无铅中毒表现的接触工人中均有升高,提示这两项指标能灵敏地反映铅的损伤。建议增加染色体畸变分析作为健康监护指标,以观察铅作业工人的遗传学效应。本文还对血铅、尿铅与卟啉代谢指标间的关系进行了相关分析。The study on lead exposed workers in a battery factory showed that besides the porphyrin metabolic disturbance and increase of immature erythrocytes, the frequency of CA in exposed group was higher than that in the control group. FEP and CA were increased among the workers without the appearance of toxic signs and symptoms. It suggested that FEP and CA appeared to be sensitive to lead exposure and CA might be used as an index in the health surveilliance to observe the genetic effect during lead exposure. The correlations of the levels of PbB, PbU and the porphyrin metabolism indices were also studied.

关 键 词：铅 卟啉代谢 染色体 生物学效应 

分 类 号：R135.11[医药卫生—劳动卫生]