三个指标联合检测在糖尿病早期肾损害中的临床意义  

Clinical significance of combination detection of blood HbA1c1,urine mALB and β_2-MG in early renal damage of DM

作　　者：李静[1] 曹传勇[1] 李琛[1] 

机构地区：[1]广东医学院附属医院检验科,广东湛江524001

出　　处：《检验医学与临床》2012年第3期279-280,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨联合检测糖化血红蛋白(HbA1c),随机尿微量清蛋白(mALB)及尿β2-微球蛋白(β2-MG)3个指标在糖尿病(DM)患者早期肾损害中的临床意义。方法糖尿病肾病组、单纯糖尿病组、健康对照组均采用酶法测定糖化血红蛋白,采用散色比浊法检测β2-MG及尿微量清蛋白。结果单纯糖尿病组与健康对照组相比,上述3项指标差异有统计学意义(P<0.05),在糖尿病肾病组中,HbA1c、尿中mALB及β2-MG的含量均明显高于健康对照组和单纯糖尿病组,差异有统计学意义(P<0.01)。结论 HbA1c、mALB、β2-MG三者联合检测可作为诊断DM早期肾损害可靠而敏感的指标,为监测DM肾病发生及监护治疗的良好实验室指标。Objective To detect the levels of HbA1c,mALB and β2-MG in the patients with diabetes mellitus(DM) and to find out their significance to early renal damage of DM.Methods The level of mALB and β2-MG was measured by the immunoturbidimetry method.The level of HbA1c was measured by the enzyme method.Results Comparing the DM group with the healthy control group,these three indices showed statistical difference(P<0.05).In the diabetic nephropathy group,HbA1c and 2 kinds of protein in urine were significantly higher than those in the healthy controls and DM group,with statistical difference(P<0.01).Conclusion HbA1c,mALB andβ2-MG combined detection could be used as the reliable and sensitive indexes to diagnose early renal injury in DM,which are also better laboratory indicators for monitoring the occurrence of DM nephropathy and treatment.

关 键 词：糖化血红蛋白 尿微量清蛋白 Β2微球蛋白 糖尿病 

分 类 号：R587.2[医药卫生—内分泌]