糖耐量异常患者外周血管损害及高敏C反应蛋白、纤维蛋白原变化的临床研究  

Study on peripheral arterial damage and plasma fibrinogen,serum high sensitivity C reactive protein level in patients with impaired glucose tolerance

作　　者：袁公贤[1] 王桦[1] 汪迎晖[2] 刘珍丽[1] 夏上[1] 

机构地区：[1]武汉大学中南医院综合科,430071 [2]武汉大学中南医院超声影像科,430071

出　　处：《疑难病杂志》2012年第2期107-109,共3页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的观察糖耐量异常(IGT)患者高敏C反应蛋白(hs-CPR)、纤维蛋白原(Fib)水平和血管损害程度的变化。方法按照1999年WHO和2003年ADA诊断标准,将116例入选者分为IGT组(n=52)和对照组(健康体检者,n=64),生化分析仪和血凝仪分别检测hs-CRP、Fib值,并检测肱—踝动脉脉搏波传导速度(baPWV)、踝—臂指数(ABI)值。结果 IGT组baPWV(cm/s)显著高于对照组(1564.83±223.24 vs 1477.68±194.78,P<0.05),IGT组ABI值显著低于对照组(1.12±0.13 vs 1.18 4±0.17,P<0.05),其hs-CRP(mg/L)、Fib(g/L)值也均高于对照组(1.57±0.50 vs 1.12±0.35,P<0.01;2.95±0.52 vs 2.46±0.37,P<0.01);进一步分析baPWV>1400 cm/s时,IGR组hs-CRP(mg/L)、Fib(g/L)值仍显著高于对照组(1.72±0.52 vs 1.26±0.57,P<0.01;3.32±0.63 vs 2.60±0.60,P<0.01)。结论糖耐量异常患者血管弹性减退,血hs-CRP、Fib水平显著增高。Objective To investigate the changes between the levels of plasma Fib,high sensitivity C reactive protein (hs-CRP)and the degree of peripheral arterial injury in impaired glucose tolerance(IGT)group.Methods 116 subjects were divided into IGT group(n=52) and control group(healthy subjects,n=64).Fib and hs-CRP were detected by blood biochemistry analyzer and coagulometer respectively,the baPWV,ABI were measured by non-invasive automatic waveform ana- lyzer.Results The mean baPWV(cm/s) value was higher in IGT group than that in the control group(1564.83±223.24 vs 1477.68±194.78,P<0.05).The mean ABI value in the IGT group was significantly lower than that in the control group (1.12±0.13 vs 1.18±0.17,P<0.05),and the levels of hs-CRP(mg/L) andFib(g/L) were also higher than that in the control group(1.37±0.50 vs 1.12±0.35,P<0.01;2.95±0.52 vs 2.46±0.37,P<0.01);further analysis demonstrated that once the levels of baPWV was more than 1400 cm/s,the levels of the hs-CRP(mg/L)and Fib(g/L) in the IGT group were higher than those in the control group(1.72±0.52 vs 1.26±0.57,P<0.01;3.32±0.63 vs.2.60±0.60, P<0.01).Conclusion It proved that the patients with IGT suffered from vascular injury,combined with the increase of the levels of hs-CRP and Fib.

关 键 词：糖耐量异常 并发症 脉搏波传导速度 踝-臂指数 

分 类 号：R587.1[医药卫生—内分泌]