一种新型磁共振成像造影剂的制备及性能  

Synthesis and Properties of a Novel Contrast Agent

作　　者：杨晓露[1] 杨兴旺[1] 黄燕[1] 张岐[1,2] 吴静波[1] 曹本男[2] 张小燕[1] 

机构地区：[1]江苏大学化学化工学院,镇江212013 [2]海南大学海南精细化工重点实验室,海口570228

出　　处：《高等学校化学学报》2012年第2期426-429,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20871061);江苏省科技支撑计划(批准号:SBE201077304);海南大学奖励基金(批准号:hd09xm07/24);海南省自然科学基金(批准号:209001);江苏大学学生科研立项(批准号:09A053)资助

摘　　要：通过酰化反应将窄分子量分布的低聚壳聚糖(CSn,n=6,8,11)引入到二乙三胺五乙酸(DTPA)中得到新型配体,再与Mn2+配位得到3种顺磁性Mn(Ⅱ)基配合物,其结构用IR、元素分析及电感耦合等离子体发射仪(ICP-AES)进行表征.测定了配合物的纵向弛豫率(r1),结果表明,这类造影剂的弛豫率高于商业化医用的磁共振成像对比剂Gd-DTPA.通过等温滴定微量热法(ITC)测定了功能配合物与牛血清白蛋白(BSA)相互作用的热力学参数.Chitosan oligosaccharides（CSn,n=6,8,11） with narrow molecular weight distribution and low polymerization degree were introduced into diethylenetriamine pentaacetic（DTPA） by acylation reaction.The synthesized novel ligands were coordinated to Mn2＋,then the paramagnetic Mn2＋-based complexes were gained.The structures of synthesized ligands and the corresponding complexes were characterized by IR,elemental analysis,and ICP-AES.The longitudinal relaxivities（r1） were measured.The results show that r1 of Mn-DTPA-CSn are higher than that of commercial contrast agent Gd-DTPA.Besides,the thermodynamical parameters of the interaction between the functional complexes and bovine serum albumin（BSA） were conducted by isothermal titration calorimetry（ITC）.

关 键 词：造影剂 壳聚糖 弛豫率 等温滴定微量热(ITC) 

分 类 号：O636[理学—高分子化学] O657.2[理学—化学]