成人血尿酸分布与代谢综合征及其各组分关系  

Serum uric acid and its association with metabolic syndrome and its components in rural adult residents

作　　者：金善姬[1] 朴鲜女[2] 熊英环[2] 方今女[2] 

机构地区：[1]延边大学附属医院检验科,吉林延吉133000 [2]延边大学基础医学院

出　　处：《中国公共卫生》2012年第2期163-165,共3页Chinese Journal of Public Health

基　　金：国家自然科学基金(3026009830860244);吉林省教育厅基金项目(20082)

摘　　要：目的探讨血尿酸分布特征与代谢综合征(MS)及其各组分的相关性。方法检测4 771名吉林延边农村居民血样本尿酸及代谢相关指标,根据《中国成人血脂异常防治指南》建议的标准诊断MS。结果多因素Logistic回归分析结果表明,模型1:调整性别、民族、年龄、文化程度、吸烟及饮酒,MS及其各组分的患病危险均随血尿酸水平呈升高趋势;模型2:调整模型1中的变量和MS其他各组分,除高血糖外MS其他组分的患病危险均随血尿酸水平呈升高趋势;模型3:调整模型2中的变量和整体肥胖,结果与模型2一致,仅OR值有所下降;模型4:调整模型1中的变量和MS各组分,整体肥胖的患病危险随血尿酸水平呈升高趋势。协方差分析结果表明,MS组和非MS组血尿酸水平存在差异(F=170.3,P=0.000),且随MS组分数目的增加血尿酸水平呈升高趋势(趋势F=200.0,P=0.000)。结论延边地区成人血尿酸水平与MS及其组分(除高血糖)、整体肥胖明显相关;随MS组分数目的增加血尿酸水平呈升高趋势。Objective To explore the concentration of serum uric acid（SUA） and its association with metabolic syndrome（MS） and its components in rural residents of Yanbian area.Methods A cross-sectional survey was conducted and concentration of SUA and the indexes associated MS were measured in 4 771 rural residents（1 996 males aged 49.9±11.1 years,2 775 females aged 50.3±11.5 years）.MS was diagnosed according to the criteria of ＂Prevention and Treatment of Blood Lipid Abnormality in Chinese Adult＂.Results Logistic regression analyses showed that MS and its all components were significantly associated with concentrations of SUA after adjusting for sex,race,age,smoking,and alcohol drinking and the prevalence of MS and its components increased with the increment of SUA in model A.There were significant associations between the components（except hyperglycemia） of MS and the concentration of SUA after adjusting for the same set of variables in model A plus the other components of MS in model B.The same results were showed after adjusting for the same set of variables in model B plus general obesity.The general obesity was significantly associated with the concentration of SUA after adjusting for the same set of variables in model A plus all components of MS.The concentrations of SUA were significantly higher among the people with MS than those without MS（F=170.3,P=0.000） and SUA concentration increased along with the number of MS conponent（F=200.0,P=0.000）.Conclusion Among rural residents of Yanbian area,concentration of SUA is strongly associated with the prevalence of MS and its components and increases along with the number of MS component.General obesity is significantly associated with SUA concentration.

关 键 词：血尿酸 代谢综合征及其各组分 患病率 相关性 

分 类 号：R181.38[医药卫生—流行病学]