胆固醇水平对慢性心力衰竭患者预后的影响  

Prognostic significance of cholesterol level in chronic heart failure

作　　者：戴丽莹[1] 干倩[1] 周清芬[1] 任妍[1] 虞莹珺[1] 张凤如[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院心内科,200025

出　　处：《国际心血管病杂志》2012年第1期53-55,共3页International Journal of Cardiovascular Disease

摘　　要：目的:探讨总胆固醇(TC)水平对于慢性心力衰竭(CHF)患者预后的影响。方法:入选1995年至2010年805例CHF患者,按TC水平为4个亚组:TC≤160 mg/dl、TC161～200 mg/dl、TC201～239 mg/dl及≥240 mg/dl组,探讨血脂水平、其他实验室指标及超声心动图指标与预后的相关性。终点事件为全因死亡、心源性死亡。结果:平均随访(3.11±3.32)年,共发生199例终点事件,其中全因死亡占78.4%,心源性死亡占15.6%。亚组间生存率差异有统计学意义(P=0.036),TC降低提示生存率降低。多因素回归分析表明,TC水平是CHF终点事件的独立危险因素(OR=0.75,95%CI:0.62～0.89,P=0.002)。结论:TC水平是CHF死亡的独立危险因素。Objective：This study examined the prognostic significance of serum cholesterol level in patients with chronic heart failure （CHF）. Methods： A total of 805 patients with CHF were divided into four subgroups according to serum total cholesterol level. Detailed clinical information was collected from review of hospital medical records. End point was defined as all-cause death or cardiac death. Results： During follow-up（3.11 ± 3.32）year, 199 patients died. In multivariate logistic analysis, cholesterol level was a significant independent risk factor for mortality（OR = 0.75,95 % CI： 0.62 - 0.89, P = 0. 002）. Conclusion：Cholesterol levels independently predict adverse clinical outcome in patients with CHF.

关 键 词：慢性心力衰竭 胆固醇 预后 

分 类 号：R541.6[医药卫生—心血管疾病]