20％的硫酸镁在成人重症破伤风中的治疗作用  

The 20 % magnesium sulfate for the treatment of the adult severe tetanus

作　　者：魏刚[1] 章希[2] 张必翔[1] 刘文[2] 陈孝平[1] 张应天[2] 

机构地区：[1]华中科技大学同济医学院附属同济医院普外科,武汉430030 [2]江汉大学附属医院普外科,武汉430015

出　　处：《国际外科学杂志》2012年第1期11-13,共3页International Journal of Surgery

摘　　要：目的探讨20％的硫酸镁治疗成人重症破伤风的安全性及有效性。方法对2005年4月-2010年10月收治的27例成人重症破伤风住院病例行回顾性分析。结果血镁超过4mmol／L者2例（2／27，7．4％）；气管切开者25例（25／27，92．6％），机械通气22例（22／25，88．0％），机械通气时间为4—16d，平均（7．5±3．7）d；肺部感染25例（25／27，92．6％）；死亡4例（4／27，14．8％）；治愈23例（23／27，85．2％），住院时间25～48d，平均（32．2±18．8）d。结论20％的硫酸镁治疗成人重症破伤风安全，可有效控制肌肉强直、抽搐和自律性不稳定，以减少安定和氯丙嗪等镇静药的用量，操作简单，价格便宜，易于在临床推广。Objective To study the efficacy and safety magnesium sulfate for the treatment of adult severe tetanus. Methods Twenty-seven inpatients with adult severe tetanus during April 2005 - October 2010 were retrospectively analysed. Results The total serum magnesium more than 4 mmoL/L was found in 2 patients（ 2/27,7.40% ）. The traeheotomy was performed in 25 Patients （ 25/27,92.6% ） , 22 of which （22/25,88.0%） run mechanical ventilation with the mean mechanical ventilation time （7.5 ± 3.7 ） days, （4 to 16 days）. Pulmonary infection occurred in 25 cases （25/27,92.6%）. Twenty-three of 27 （23/27, 85.2% ） cases were cured except 4 cases died,and the mean hospital stay was （32.22 ± 18.78） days, （25 to 48 ） days. Conclusions 20% magnesium sulfate is safe for treatment of the patients of adult severe tetanus. It can control not only muscle rigidity and spasms but also autonomic instability efficaciously, and lower the dosage of sedative such as diazepam and chlorpromazine. This method is worth popularizing in clinical practice for its easy operation and low cost.

关 键 词：硫酸镁 重症破伤风 治疗 

分 类 号：R517.3[医药卫生—内科学]