溴吡斯的明阳离子脂质体体外释放和大鼠离体肠吸收  

Study on the drug release in vitro and intestinal absorption of pyridostigmine bromide cationic liposome

作　　者：张梨[1] 谭群友[2] 刘雨[1] 陶绍霖[2] 张景勍[1] 

机构地区：[1]重庆医科大学药物高校工程研究中心和生物化学与分子药理学重点实验室,重庆400016 [2]第三军医大学大坪医院野战外科研究所胸外科,重庆400042

出　　处：《中国医院药学杂志》2012年第3期164-167,共4页Chinese Journal of Hospital Pharmacy

基　　金：教育部博士点基金资助项目(编号:20095503120008);重庆市教育委员会资助项目(首批高等学校优秀人才资助;编号:KJ090308)

摘　　要：目的:制备溴吡斯的明脂质体,考察其体外释药性质及各肠段的吸收情况。方法:采用逆向蒸发法制备溴吡斯的明阳离子脂质体;透析法测定阳离子脂质体体外释放情况;并采用外翻肠囊法考察脂质体肠道吸收行为。结果:阳离子脂质体72 h累积释放(97.2±3.3)%;能增加药物在各肠段的吸收量,各肠段表观渗透系数(Papp)增加。结论:制备的阳离子脂质体具有一定的缓释效果;阳离子脂质体能够增加药物渗透性。OBJECTIVE To prepare pyridostigmine bromide cationic liposome and study the in vitro release characteristic,and to investigate absorption characteristic in various intestinal segments.METHODS Cationic liposomes were prepared by reverse phase evaporation.The release rate of pyridostigmine bromide from liposomes was also tested.Everted intestinal sac was used to study the absorption characteristic in various intestinal segments.RESULTS Pyridostigmine bromide release from cationic liposome was（97.2±3.3）% after 72 h.The absorption quantity was increased in various intestinal segments by liposome,as well as Papp.CONCLUSION The liposomes possess a sustained release property in vitro.Permeability of pyridostigmine bromide was enhanced by preparation of cationic liposome.

关 键 词：溴吡斯的明 阳离子脂质体 体外释放 肠吸收 

分 类 号：R94[医药卫生—药剂学]