不同粒度五味子有效利用率评价  

The Effective Utilization Rate Evaluation of Different Particle Size Fructus Schisandrae

作　　者：苏桃[1] 陆兔林[1] 毛春芹[2] 胡俊扬[1] 蔡宝昌[1] 

机构地区：[1]南京中医药大学江苏省中药炮制重点实验室,南京210046 [2]南京中医药大学药学院,南京210046

出　　处：《中国实验方剂学杂志》2012年第3期96-99,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技部重大新药创制项目(2009ZX09308-004);江苏省教育厅重大项目(09KJA360001);南京中医药大学科技项目(10XJC06)

摘　　要：目的:比较不同粒度五味子饮片中五味子醇甲等6种木脂素成分含量来确定临床最佳有效利用率的研究。方法:通过HPLC法同时测定同一来源、不同粒径的五味子经过水煎煮后五味子醇甲等6种有效成分含量的对比情况。结果:粉碎组的五味子醇甲等6种木脂素成分含量明显高于不粉碎组;50,65,80,100目粉碎的五味子中五味子醇甲等6种木脂素成分含量随粒度的变细而增高,但差异性不明显。结论:粉碎组优于不粉碎组;粒度越细,加大了工作成本,故临床使用五味子时以过三号筛(50目)粗粉为宜。Objective： To compare the 6 lignans components content such as schizandrol A in different granularity of Schisandra chinensis in order to confine clinical best effective utilization rate.Method： Through the high-performance liquid chromatography（HPLC） to determinate 6 lignans components content such as schizandrol A in different granularity of Schisandra chinensis after water decoction to contrast the effective component utilization rate.Result： The crushed group of Schisandra chinensis was obviously higher than the not crushed group about the 6 lignans components content such as schizandrol A.The contents of 6 compounds in 50,65,80,100 mesh of crushed Schisandra chinensis were increased with the particle size reduction,but there was a little differences.Conclusion： The crushed group is well than the not crushed group,the fine particle size increased the cost of work,So when clinical use in Fructus Schisandrae should advisable of using the 50 mesh thick powder.

关 键 词：五味子 高效液相色谱法 不同粒度 五味子醇甲 有效利用率 

分 类 号：R284.1[医药卫生—中药学]