赤雹果乙醇提取物对子宫内膜炎继发性痛经作用研究  

Syudy on Effects of Alcohol Extract of Thladiantha dudia Fruits on Secondary Dysmenorrhea Induced by Endometritis

作　　者：李亚洲[1] 高冲[1] 胡晓丞[1] 刘玉玲[1] 佟继铭[1] 

机构地区：[1]河北省中药研究与开发重点实验室,承德医学院,河北承德067000

出　　处：《中国实验方剂学杂志》2012年第3期153-155,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河北省自然科学基金项目(C200600863);河北省教育厅项目(2005225)

摘　　要：目的:观察赤雹果乙醇提取物(AETF)对子宫内膜炎继发性痛经的治疗作用。方法:采用大鼠子宫内植入塑料管法,诱发子宫内膜炎继发痛经模型。术后第2天开始灌胃(ig)给药,AETF低、中、高剂量(0.3,0.6,1.2 g.kg-1)连续7 d。以子宫的肿胀度,血液流变学(全血黏度、血浆黏度、红细胞聚集率)及子宫组织中PGE2含量为指标,观察AETF治疗继发性痛经的作用。结果:AETF 0.3,0.6,1.2 g.kg-1剂量组大鼠的子宫肿胀度、血浆黏度、红细胞聚集率均显著低于模型组(P<0.01或P<0.05);1.2 g.kg-1剂量组大鼠全血黏度显著低于模型组(P<0.01);0.6,1.2 g.kg-1剂量组大鼠子宫组织中的PGE2含量显著低于模型组(P<0.05)。结论:AETF治疗子宫内膜炎继发性痛经的作用与血液流变学指标的改善、子宫组织中PGE2含量的降低有关。Objective： To observe the effects of the alcohol extract of Thladiantha dudia fruits（AETF） on secondary dysmenorrhea induced by endometritis.Method： The secondary dysmenorrhea model of endometritis was established by implanting the plastic tube into uterus.Degree of uterus edema,hemorheology（blood viscosity,blood plasma viscosity,erythrocytes aggregation）and concentration of prostaglandin E2（PGE2） were observed.Result： AETF 0.3,0.6,1.2 g·kg-1groups clearly decreased blood plasma viscosity and erythrocytes aggregation,depressed degree of uterus edema,as compared with model group（P0.01 or P0.05）.AETF 1.2 g·kg-1group clearly decreased blood viscosity,compared with model group（P0.01 or P0.05）.AETF 0.6,1.2 g·kg-1groups clearly decreased concentration of PGE2 in the uterus,compared with model group（P0.05）.Conclusion： The effects of AETF on secondary dysmenorrhea induced by endometritis are related to amelioration of hemorheology and reduction of PGE2 concentration.

关 键 词：赤雹果乙醇提取物 继发性痛经 血液流变学 前列腺素E2 

分 类 号：R285.5[医药卫生—中药学]