microRNA——药物开发的新靶点  

microRNA——a new target for drug development

作　　者：王颖秋[1] 刘艳[1] 胡又佳[1] 

机构地区：[1]上海医药工业研究院创新药物与制药工艺国家重点实验室,上海200437

出　　处：《上海医药》2012年第3期31-35,共5页Shanghai Medical & Pharmaceutical Journal

摘　　要：微小RNA(micro RNA)是一类长约22nt的非编码单链RNA,由前体经酶作用而得,它是细胞的内源性物质,普遍存在于动植物中,高度保守,在生命体的生长、发育、疾病发生发展的过程中起到了基因调控作用,它与重大疾病,如肿瘤、心脏疾病、神经性疾病等都有着密切的关联,因此成为新药开发的一个重要新靶点,以它为靶点的药物设计和药物研发工作也在不断探索中。本文就其研究的历史、生物合成和作用机制、生物功能、与疾病的关系以及以microRNA为靶点的药物设计的研究情况做一个简单的综述。microrNA is a class of ~22 nt small non-coding single chain rNA which is an endogenous substance and produced from precursor through enzymatic reaction. microrNAs are highly conserved and are ubiquitous in both animals and plants. They act as the regulators in the growth and proliferation of cells,and play an important role in the development of many diseases. These make microrNAs become promising new targets for the discovery of new drugs. A lot of research works have been involved in studying and designing novel drugs targeting microrNAs. In this paper,the discovery,biosynthesis and mechanism as well as biologic function of microrNA are reviewed.

关 键 词：微小RNA 药物开发 靶点 

分 类 号：R91[医药卫生—药学]