脑靶向给药系统研究进展  

Progress in Drug Delivery System for Brain Targeting

作　　者：王爽[1] 李其禄[2] 翟光喜[1] 

机构地区：[1]山东大学药学院,山东济南250012 [2]山东大学校医院,山东济南250012

出　　处：《中国医药工业杂志》2012年第2期137-142,共6页Chinese Journal of Pharmaceuticals

基　　金：教育部留学回国人员科研启动基金课题(教外司留[2010]609号)

摘　　要：血-脑屏障阻碍药物进入脑组织,不利于中枢神经系统疾病的治疗。本文介绍了近年来脑靶向给药系统的研究进展,包括通过受体(如载脂蛋白受体、转铁蛋白受体等)介导的主动靶向系统、被动靶向系统(如纳米粒、碳纳米管等)及其他靶向系统(如磁性微粒、阳离子制剂等)。Many therapeutic drugs can not successfully enter brain due to blood-brain barrier, which is a challenge for the treatment of central nervous System diseases. Research progress in drug delivery system for brain targeting, including active targeting system induced by receptor （such as apoprotein receptor, transferrin receptor）, passive targeting system （such as nanoparticles, carbon nanotubes） and other targeting system （such as magnetic particles, cationic prenaration）, is summarized in this paper.

关 键 词：脑靶向 给药系统 血-脑屏障 综述 

分 类 号：R944.9[医药卫生—药剂学]