糖足方对糖尿病足筋疽大鼠后爪部肌腱糖化损伤的保护作用  

Protective Effects of "Tangzu Prescription" on Tendon Saccharification Damage in Rats with Diabetic Foot Ulcer

作　　者：张磊[1] 刘立昌[2] 王义成[3] 曹烨民[3] 奚九一[3] 

机构地区：[1]上海中医药大学附属曙光医院,上海201203 [2]广东省深圳市第二人民医院,广东深圳518035 [3]上海市中西医结合医院,上海200082

出　　处：《上海中医药大学学报》2012年第1期78-81,共4页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：上海市浦东新区卫生系统重点学科群建设资助项目(PWZxkq2010-04);上海市教育委员会重点学科(第5期)建设项目资助(J50307)

摘　　要：目的:探讨糖足方对糖尿病大鼠足部肌腱糖化损伤的保护作用。方法:将Wistar大鼠随机分为正常组、模型组、中药预防组、中药治疗组、西药治疗组,并采取腹腔一次性注射链脲佐菌素(STZ)复制Wistar大鼠糖尿病模型。中药预防组在成模后即灌胃糖足方煎剂,中药治疗组、西药治疗组(予氨基胍水溶液)均在成模后1月灌胃给药。于实验第12周处死,观察大鼠后爪部肌腱组织病理变化及检测血糖、组织糖含量、果糖胺(FMN)及组织糖基化终产物(AGEs)。结果:中药预防组和中药治疗组均可明显改善糖尿病大鼠后爪部肌腱组织病理损害,降低组织糖含量,且预防组优于治疗组,而西药无此作用;中药预防组和西药治疗组均可显著降低FMN、AGEs,而中药治疗组只有降低AGEs作用。结论:糖足方对糖尿病大鼠足部肌腱糖化损伤有保护作用,且早期干预效果更佳。Objective： To investigate the protective effects of ＂Tangzu Prescription＂ on tendon saccharification damage in rats with diabetic foot ulcer.Methods： The rat models were duplicated by abdomenal injection of streptozocin,and randomized into normal group,model group,TCM prevention group,TCM treatment group and western medicine group.The models were established and treated with ＂Tangzu Prescription＂ in TCM prevention group by gastric gavage.After the models were established in one month,the rats in TCM treatment group and western medicine group were treated with ＂Tangzu Prescription＂ and amino guanidine solution by gastric gavage.The rats were sacrificed at 12 weeks,then the pathologic changes,blood glucose,tissue glucose,FMN and AGEs were detected.Results： TCM prevention group and TCM treatment group had obvious effects to improve the pathologic damage of tendon tissues in diabetic rats and lower tissue glucose levels;and the effects of prevention group was better than that of treatment group,without such effects in western medicine group.The TCM prevention group and western medicine group had effects to lower FMN and AGEs,and TCM treatment group had the effects to lower AGEs.Conclusion： ＂Tangzu Prescription＂ has protective effects on tendon saccharification damage in rats with diabetic foot ulcer,with better effects when given at early stage.

关 键 词：糖足方 糖尿病足 筋疽 糖化损伤 

分 类 号：R285.5[医药卫生—中药学] R587.2[医药卫生—中医学]