芹灵冲剂的退黄降酶作用  

Action of qinling chongji on recded jaundice and reduced enzyme

作　　者：黄正明[1] 杨新波[1] 曹文斌[1] 陈鸿雁[1] 张敬珍[1] 刘军[2] 

机构地区：[1]中国人民解放军北京军医学院药理教研室,北京100071 [2]中国人民解放军第307医院生化检验科,北京100083

出　　处：《解放军药学学报》2000年第1期12-15,共4页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：全军"九五"重点科研基金资助!课题[No(1996) 科训字第96 号

摘　　要：目的：观察芹灵冲剂的退黄降酶作用，以评价芹灵冲剂的退黄降酶效果。方法：在四氯化碳（ＣＣｌ４）、Ｄ－半乳糖胺（Ｄ－Ｇａｌａ）和α－萘异硫氰酸酯（ＡＮＩＴ）３种化学性肝损伤大鼠模型和在体乙型肝炎（ＤＨＢＶ）鸭，用全自动生化测定仪分别测定动物的肝功能。结果：芹灵冲剂５ｇ·ｋｇ－１和１０ｇ·ｋｇ－１能显著降低ＣＣｌ４和Ｄ－Ｇａｌａ肝损伤大鼠血清谷丙转氨酶（ＡＬＴ）水平。能明显降低ＡＮＩＴ肝损伤大鼠血中胆红素（ＳＢ）含量；对ＤＨＢＶ性肝炎鸭血中ＡＬＴ和ＳＢ水平的升高也有一定降低作用。结论：芹灵冲剂对大鼠化学性肝损伤和鸭乙型肝炎均有显著的退黄降酶作用。Aim To observe the effect of receted jaundice and reduced enzyme of Qin Ling Chong Ji (QL) on rats models of chemical hepaticinjury and duck hepatitis models of duck hepatitis B viru (DHBV) infected nestling ducks were studied respectively in this paper.Methods Three hepatic injury rat models of CCl 4、D-Gala、ANIT and duck hepatitis B animal models were used and the index of liver function were judged by the recded jaundice and reduced enzyme of QL in the experiments respectively.Results The examined result of liver function showed that In CCl 4 and D-Gala intoxicating rats models,aftre treatment with QL (QL 5g·kg -1 and 10g·kg -1 ) PO,the serum ALT were significantly lower than the control groups respectively.In ANIT (a-Naphythalisocyanate) intoxicating rats model,the serum bilirubin (SB)and ALT were also significantly lower than the control groups respectively.In DHBV duck models,the serum bilirubin (SB)and ALT were also significantly lower than the control groups respectively.Conclusio The results suggested that QL has the effect of decreasing the content of ALT、AST and SB on chemical hepatic injury and DHBV infected ducks.

关 键 词：芹灵冲剂 退黄降酶 中药 药理 

分 类 号：R286.55[医药卫生—中药学] R285.5[医药卫生—中医学]