糖肾胶囊对FFR胰岛素抵抗性与leptin浓度的影响  

Effect of Tangshen Capsule on Insulin Resistance and Leptin Levels in Fructose Fed Rats

作　　者：李怡[1] 张前进[2] 李秋贵[1] 常志彦[1] 高凤芝[1] 李文瑞[1] 邱文升 

机构地区：[1]卫生部北京医院瑞东糖尿病中西医结合研治中心,北京100730 [2]北京医科大学第一附属医院,北京100034

出　　处：《中国实验方剂学杂志》2000年第1期25-27,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金资助课题

摘　　要：观察糖肾胶囊对高果糖餐大鼠模型的胰岛素抵抗性与leptin 水平的影响。结果糖肾胶囊对大鼠的收缩期血压无显著改善作用;胰岛素敏感性( 即胰岛素抵抗性改善) 指标M 值及leptin 浓度,TSJN 组较FFR组有非常显著的差异,与空白组比较无显著差异;M 值与血浆leptin 浓度呈非常显著的负相关关系。The effect of Tangshen capsule on insulin resistance and leptin levels was investigated in fructose fed rats.The result showed that the systolic pressure of the rats in Tangshen capsule group has no improvement.M value and leptin concentration,the parameters for the improvement of insulin sensitivity,were significantly different between Tangshen capsule group and FFR group,but no obvious difference was found between Tangshen capsule group and control group.M value showed a significantly negative correlation with the plasma leptin.

关 键 词：胰岛素抵抗 高果糖餐大鼠 瘦素 糖肾胶囊 中药 

分 类 号：R286.715[医药卫生—中药学]