pH敏感的分子筛组装体药物缓释性能研究  

Study on Drug Delivery Property of the pH-sensitive Molecular Sieve Systems

作　　者：李晓丰[1] 王宇[2] 于霁厚[3] 

机构地区：[1]东北石油大学华瑞学院,黑龙江哈尔滨150025 [2]哈尔滨师范大学化学化工学院,黑龙江哈尔滨150025 [3]黑龙江省科学院石油化学研究院,黑龙江哈尔滨150040

出　　处：《黑龙江科学》2012年第1期1-4,共4页Heilongjiang Science

基　　金：黑龙江省教育厅项目"基于介孔分子筛的pH敏感的药物载体的研究"(编号:11551121)

摘　　要：合成了一种新型的pH敏感药物靶向释放系统,该系统以pH敏感的壳聚糖作为包裹剂,对载药后的COOH/SBA-15片剂进行包裹。研究了该系统的pH敏感释放性能。结果表明,该药物组装体中盐酸二甲双胍分子在胃液中释放受到抑制,而在小肠液中能够释放,因此可以达到药物靶向释放的效果,从而能够极大地增加药效。In this article, a novel pH-sensitive targeting of drug delivery systems was synthesized, after loading drug for COOH/SBA-15 tablet, the sample was coating using pH-sensitive chitosan as a package agent. The pH-sensitivc release performance of the system was studied. The results showed that the assembly release in drug molecules was inhibited in the gastric juice, while it may be released in the small intestine so that the effect of targeted drug molecules release can be achieved, which can greatly increase the drug efficacy.

关 键 词：COOH/SBA-15 壳聚糖 盐酸二甲双胍 PH敏感 靶向释放 

分 类 号：TQ460.31[化学工程—制药化工]