响应面法优化苦参碱粗品的结晶纯化过程  

Optimization of the matrine crude product using response surface methodology

作　　者：秦学功[1] 刘冰[1] 吴志军[1] 

机构地区：[1]黑龙江八一农垦大学生命科学技术学院,黑龙江大庆163000

出　　处：《化学工程师》2012年第1期12-15,共4页Chemical Engineer

摘　　要：通过Box-Behnken试验设计,系统地考察了料液比、温度及结晶时间3个因素对苦参碱结晶收率的影响,并运用响应面法对建立的二次回归模型进行了综合分析。结果表明,当料液比为1∶28.78、温度为59.19℃、时间为30min时,苦参碱的结晶收率最大,其值为97.16%。The Box-Behnken design combined with response surface methodology was used to optimize purification by crystallization.Second-order multiple regression analysis was used to build a predicted model of the combined effects of independent variables（the solid-liquid ratio,temperature and crystallization） for maximum the yield of matrine crystallization.The optimized condition was solid-liquid ratio is 1∶28.78,temperature is 59.19℃,the time is 30 min,in this case,the yield of matrine crystallization up to 97.16%.

关 键 词：苦参碱 结晶纯化 响应面法 

分 类 号：R284.1[医药卫生—中药学]