海洛因依赖者TT病毒感染  

Infection of TT Virus in Heroin Addicts

作　　者：张智[1] 张珍[1] 苏红梅 

机构地区：[1]解放军第一七七中心医院,广东广州510317

出　　处：《中国医师杂志》2000年第1期24-25,28,共3页Journal of Chinese Physician

摘　　要：为了解海洛因依赖者ＴＴ 病毒感染状况、研究其致病性及病毒特征，探讨感染传播途径，采用巢式ＰＣＲ 和ＥＬＩＳＡ 法检测２８６ 例海络因依赖者血清ＴＴ病毒ＤＮＡ 和抗体ＩｇＧ。结果显示：２８６ 例血清标本ＴＴ 病毒ＤＮＡ 和抗体ＩｇＧ的阳性率分别为７－０ ％ 和９－４％ ；无一例标本同时检出ＴＴ 病毒ＤＮＡ 和抗体ＩｇＧ；ＡＬＴ 升高和正常组ＴＴ 病毒感染阳性率差异无显著性（ Ｐ＞０－０５） 。结果显示：海洛因依赖者存在ＴＴ 病毒感染和无症状携带状态，感染不依赖其它肝炎病毒而单独存在；ＴＴ病毒可能是一种新的自限性ＤＮＡ病毒，其对肝脏的损害作用不确切；静脉注射不是海洛因依赖者ＴＴ病毒感染的主要途径。To understand the infective status and study the pathogenic role of TT virus and the viral characteristics,and elucidate the pathway of transmission of TT virus in heroin addicts,nested-polymerase chain reaction and enzyme-linked immunosorbent assay(ELISA) were used to detect TT virus DNA and anti-TT virus IgG in 286 sera samples from patients.The positive rates of TT virus DNA and anti-TT virus IgG were 7 0% and 9 4%;respectively.None sample was positive both TT virus DNA and anti-TT virus IgG.The positive rates of TT virus DNA were no significant difference between in the elevated and in the normal alanine aminotransferase(LAT) levels groups(χ 2=0 054,P>0 05).There are TT virus infection and asymptomatic status in the heroin addicts,the infection of independent of other hepatitis virus could exist alone.TT virus is probably a new self-limited DNA virus and the biochemical or the histological evidence of significant liver damage were not seen.TT virus may not be transmitted mainly by infection of vein in heroin addicts.

关 键 词：TT病毒 海洛因依赖 PCR ELISA 

分 类 号：R512.6[医药卫生—内科学]