氟比洛芬酯超前镇痛对微创经皮肾镜手术(mPCNL)术后疼痛的影响  

Effect of preemptive analgesia with flurbiprofen axetil after minimally percutaneous nephrolithotomy

作　　者：曾凯辉[1] 罗燕华[1] 叶靖[1] 张兴洁[1] 岑燕遗[1] 赵子良[1] 

机构地区：[1]广州医学院第一附属医院麻醉科,广东广州510120

出　　处：《海南医学》2012年第2期59-61,共3页Hainan Medical Journal

摘　　要：目的观察氟比洛芬酯对微创经皮肾镜手术(mPCNL)后疼痛治疗效果的影响。方法将40例ASAⅠ～Ⅱ级成人择期行微创经皮肾镜手术患者,随机分成K组和N组,每组20例。K组于麻醉后、手术开始前10min静脉注射氟比洛芬酯1mg/kg,N组于麻醉后静脉注射生理盐水。术前(入室时,T0)、术后2h(T1)、4h(T2)、12h(T3)、24h(T4)采用VAS法进行疼痛评分并记录不良反应。结果手术后K组与N组VAS评分差异有统计学意义(P<0.05),K组各观察时点的VAS评分均低于N组,但是两组术后患者生命体征基本平稳,两组之间差异无统计学意义(P>0.05)。结论在微创皮肾镜手术(mPCNL)术前,单次用氟比洛芬酯1mg/kg于围手术期镇痛具有确切疗效,并且操作方法简单和具有安全性。Objective To observe the effect of flurbiprofen axetil on preemptive analgesia after minimally percutaneous nephrolithotomy（mPCNL）.Methods Forty ASAⅠⅡadult patients of ASAⅠ~Ⅱ undergone scheduled for mPCNL were randomly divided into group K and group N,each had with 20 cases.Each pPatient in group K in anesthesia,10 minutes before the surgery was received intravenous injectiona blous of 1 mg ·/kg-1 flurbiprofen axetil in anesthesia,10 minutes before surgery,while those in Group N was were administered with saline intravenously after anesthesia.Pain was scored by visual analogue scale（VAS） and the adverse reactions were recorded Preoperative preoperative（The home invasion,T0）,2 h after 2 h（T1）,4 h（T2）,12 h（T3）,24 h（T4） after surgery,method using the Visual analogue scale（VAS） pain score and record adverse reactions.Results There were a statistically significant difference of the VAS scores between the two groups（P0.05）.The VAS scores in group K at each time points were lower than those in group N,but there were no statistically significant differences in patients＇ vital signs between two groups（P0.05）.Conclusion Before mPCNL,single use of flurbiprofen axetil is effective for preemptive analgesia,characterized by simple operationhas and good safety.

关 键 词：氟比洛芬酯 超前镇痛 微创经皮肾镜手术 

分 类 号：R699.2[医药卫生—泌尿科学]