鞘脂代谢及其相关疾病研究进展  

Research Progress of Sphingolipid Metabolism and Related Diseases

作　　者：孙九丽[1] 林慧珍[1] 苟萍[1] 

机构地区：[1]新疆大学生命科学与技术学院,新疆乌鲁木齐830046

出　　处：《生物技术》2011年第5期93-97,共5页Biotechnology

基　　金：国家自然基金项目(编号:307601310)资助

摘　　要：近年对鞘脂代谢及其产物的研究越来越多。鞘脂及其代谢产物不仅是构成细胞膜的重要结构分子,而且参与调节细胞的生长、分化、衰老和细胞程序性死亡等许多重要的信号转导过程,使细胞产生各种不同的生物学功能。该文综述了鞘脂代谢途径的重要酶,鞘脂及其代谢产物的功能,以及它们与相关疾病的研究进展,并就其存在的问题和今后可能的研究方向做出展望。为鞘脂代谢的过程和鞘脂相关疾病的生理病理学研究提供重要的理论依据。In recent years,the study of sphingolipids and their metabolites are becomed more and more.They are not only important structural elements of the cell membrane but also involved in regulating cell growth,differentiation,senescence,programmed cell death,and many other important signal transduction,which cells are confered a variety of biological functions.This paper reviews the importance enzymes in sphingolipid metabolism,functions of sphingolipids and their metabolic products,and their research progress related to diseases,and makes prospects for its existence problems and possible future research directions.It will provid important theoretical basises for sphingolipid metabolism and physiology and pathology of their related diseases.

关 键 词：鞘脂 神经酰胺 鞘氨醇 鞘磷脂 

分 类 号：Q71[生物学—分子生物学]