磁共振波谱(MRS)对胶质瘤切除程度评估的初步研究  

The evaluation of MRS on the excision of glioma: the initial study

作　　者：梁朝峰[1] 王辉[1] 邹艳[2] 李文胜[1] 康庄[2] 蔡梅钦[1] 郭英[1] 

机构地区：[1]中山大学附属第三医院神经外科,广州510630 [2]中山大学附属第三医院放射科,广州510630

出　　处：《中国临床解剖学杂志》2012年第1期40-43,共4页Chinese Journal of Clinical Anatomy

基　　金：国家自然科学基金(30901542);广东科技计划项目(2009B030081135)

摘　　要：目的探讨术前后MRS在胶质瘤手术切除程度评估的应用价值。方法对16例胶质瘤患者术前术后行常规MRI和3D多体素MRS检查,计算术前后的Cho/Cr和Cho/NAA的比值,寻找相等或相近的Cho/Cr和Cho/NAA比值,结合体素所在层面的位置,建立对应关系,从而评价术后切除到达范围。同时术中收集"瘤周组织"作病理检查,评估切除程度,与3D多体素MRS评估结果相比较。结果16例病人收集到完整的影像学和病理学资料有11例,病理评估为3例全切除,8例为大部分切除;3D多体素MRS评估为2例全切除,9例为大部分切除,评估结果与术后病理评估结果无显著性差异(P>0.05)。结论无创性评估胶质瘤切除程度是MRS的一项新应用,具有良好的发展前景。Objective To investigate clinical values of preoperative and postoperative magnetic resonance spectroscopy（MRS） on the excision of glioma.Methods 16 patients with glioma were checked by routine magnetic resonance imaging（MRI） and 3D-MRS before and after operation,calculated and analyzed the ratio of Cho/Cr and Cho/NAA respectively.The excision area was assessed according to the position and corresponding relation of the tumors.As well,specimen tissue around the ＇tumor＇ was collected during the operation to make pathologic examinations,for confirming the excision degree and compared it to MRS results.Results Integrated MRS and pathologic data were collected from 11 cases.According to the pathologic standard,3 cases were complete excision,8 cases were partial excision.However,3D-MRS presented 2 cases of complete excision,and 9 cases of partial excision.There was no significant difference between two way（P 0.05）.Conclusions It is a new application of MRS for evaluating excision degree of glioma noninvasively.

关 键 词：磁共振波谱 胶质瘤 切除程度 

分 类 号：R604[医药卫生—外科学]