苯妥英钠致药物超敏反应综合征1例  

One Case of Dilantin Leading to Drug Rash with Eosinophilia and Systemic Symptoms

作　　者：胡金华 程书权 全毅 黄成军 冼永超 

机构地区：[1]广西壮族自治区桂林市第三人民医院肝病科,广西桂林541000

出　　处：《中国皮肤性病学杂志》2012年第2期157-159,共3页The Chinese Journal of Dermatovenereology

摘　　要：患者男,30岁,癫痫病史13年,因口服含苯妥英钠的抗癫痫中成药物1月诱发药物超敏综合征(DIHS),并以全身弥漫性猩红热样皮疹、肝功能衰竭为主要表现。经肾上腺糖皮质激素、人免疫球蛋白、胆红素吸附+血浆置换术、护肝解毒等综合治疗后好转出院。出院后1周因肢体抽搐再次服药后两次出现前述类似表现。经停药、对症治疗康复。随访24周,未复发。A 30-year-old male patient,had an Epilepsy history of 13 years,having undergone one-month oral administration of antiepileptic drugs containing dilantin,had a drug-induced Hypersensitivity Syndrome（DIHS）,with main features including diffusive scarlatiniform rash in the whole body and liver failure.After a comprehensive treatments by adrenal cortical hormone,people immunoglobulin,bilirubin plasmapheresis and liver detoxification etc,he was improved and discharged.A week later,syndromes mentioned above re-occurred after having taken twice the medications for another body twitching.With drug withdrawal and corresponding symptomatic treatment,the patient then recovered.Following-up 24 weeks found no recurrence.

关 键 词：苯妥英钠 药物超敏反应 猩红热样皮疹 重型肝炎 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]